Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4QTBN)

• Drug Name: Isotretinoin Drug Info
• Synonyms: Accutane; Amnesteem; Claravis; Isotane; Isotretinoine; Isotretinoino; Isotretinoinum; Isotrex; Roaccutan; Roaccutane; Roacutan; Sotret; Teriosal; Neovitamin A acid; R 3255; Ro 4 3780; Ro 43780; Accutane (TN); Amnesteem (TN); BML2-E07; CIP-Isotretinoin; Claravi (TN); Clarus (TN); Decutan (TN); Isotane (TN); Isotretinoin (USP); Isotretinoin Zinc Salt, 13 cis Isomer; Isotretinoine [INN-French]; Isotretinoino [INN-Spanish]; Isotretinoinum [INN-Latin]; Izotek (TN); Oratane (TN); Ro 4-3780; Ro-43780; Roaccutane (TN); Sotret (TN); Isotretinoin [USAN:INN:BAN]; Ro-4-3780; Isotretinoin Zinc Salt, 13-cis-Isomer; (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid; (2Z,4E6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid; (7E,9E,11E,13Z)-retinoic acid; 13-RA; 13-cis RA; 13-cis-Vitamin A acid; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic acid
• Therapeutic Class: Antiacne Agents
• Cross-matching ID:
  PubChem CID: 5282379
  ChEBI ID: CHEMBL547
  CAS Number: CAS 4759-48-2
  TTD Drug ID: D00DKK
  INTEDE Drug ID: DR0890
  ACDINA Drug ID: D00335

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Spliceosome	2.25	0.00e+0	101/150 (67.33%)	HSPA8;PUF60;LSM8;...
DNA replication	2.12	0.00e+0	34/36 (94.44%)	MCM4;RFC3;MCM3;...
Ribosome biogenesis in eukaryotes	1.87	1.88e-2	52/108 (48.15%)	FBL;RPP38;NOP56;...
Terpenoid backbone biosynthesis	-1.63	4.82e-2	18/22 (81.82%)	MVK;ICMT;PCYOX1;...
Retinol metabolism	-1.65	4.08e-2	41/68 (60.29%)	RETSAT;RDH16;CYP2W1;...
Arginine and proline metabolism	-1.65	4.20e-2	39/50 (78%)	CKMT2;SAT1;PRODH;...
Alcoholism	-1.70	2.60e-2	86/186 (46.24%)	CREB5;GNB3;PDYN;...
GABAergic synapse	-1.73	2.04e-2	76/89 (85.39%)	ADCY6;PRKCG;GABRA2;...
Collecting duct acid secretion	-1.73	2.15e-2	22/27 (81.48%)	SLC12A7;ATP6V1E1;ATP6V1C1;...
Arginine biosynthesis	-1.73	2.26e-2	17/22 (77.27%)	ARG1;GOT1;CPS1;...
Porphyrin and chlorophyll metabolism	-1.73	2.25e-2	23/43 (53.49%)	UGT2A3;UGT2B15;UGT2B17;...
Amphetamine addiction	-1.74	2.39e-2	57/69 (82.61%)	GRIA4;CREB5;PDYN;...
Synthesis and degradation of ketone bodies	-1.74	2.53e-2	9/10 (90%)	OXCT1;HMGCL;ACAT1;...
Peroxisome	-1.74	2.62e-2	72/82 (87.8%)	SOD2;ABCD1;HAO2;...
Glycine, serine and threonine metabolism	-1.75	2.64e-2	31/40 (77.5%)	AMT;GCAT;PSPH;...
Drug metabolism	-1.78	2.20e-2	78/151 (51.66%)	CYP2C9;DPYS;CYP2D6;...
Aldosterone synthesis and secretion	-1.78	2.39e-2	85/98 (86.73%)	ITPR2;ADCY8;HSD3B1;...
Metabolism of xenobiotics by cytochrome P450	-1.79	1.73e-2	49/77 (63.64%)	CYP2C9;CYP2D6;ADH5;...
Butanoate metabolism	-1.80	1.43e-2	23/28 (82.14%)	OXCT1;EHHADH;HMGCL;...
Dopaminergic synapse	-1.81	1.46e-2	115/132 (87.12%)	GSK3B;PPP2R5C;CACNA1B;...
Cocaine addiction	-1.86	4.47e-3	42/49 (85.71%)	CREB5;PDYN;SLC6A3;...
Bile secretion	-1.89	5.11e-3	68/90 (75.56%)	SLC27A5;AQP8;SLC22A8;...
Alanine, aspartate and glutamate metabolism	-1.90	5.96e-3	27/37 (72.97%)	GOT1;CPS1;ABAT;...
Proximal tubule bicarbonate reclamation	-1.91	4.77e-3	21/23 (91.3%)	ATP1B3;CA4;ATP1A3;...
Cholesterol metabolism	-1.92	5.96e-3	44/50 (88%)	LIPG;APOA4;ANGPTL8;...
PPAR signaling pathway	-2.00	0.00e+0	66/74 (89.19%)	SCP2;ACOX1;PDPK1;...
Mineral absorption	-2.05	0.00e+0	48/60 (80%)	MT1X;CLCN2;ATP1B3;...
Synaptic vesicle cycle	-2.19	0.00e+0	63/78 (80.77%)	ATP6V0E1;CACNA1B;SLC1A6;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	1.11uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Fibroblast

Nasopharyngeal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
FIBRNPC	CVCL_UK07	Homo sapiens	10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
1HAEo-	CVCL_0128	Homo sapiens	10uM	24H	Show ▼
NL20	CVCL_0461	Homo sapiens	10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H	Show ▼

Normal (Fibroblast)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HFL1	CVCL_4295	Homo sapiens	10uM	24H	Show ▼
IMR-90	CVCL_0347	Homo sapiens	10uM	24H	Show ▼
WI-38	CVCL_0579	Homo sapiens	10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼