Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4RNOT)

Drug Name
MLR-1023 Drug Info
Synonyms Oral kinase activator (theraTRACE, oral, type 2 diabetes), Melior
Cross-matching ID
PubChem CID
39065
ChEBI ID
CHEMBL8030
CAS Number
CAS 41964-07-2
TTD Drug ID
D0ZU4U

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.92 1.75e-2 34/36 (94.44%) MCM3;MCM5;POLE2;...
Ribosome biogenesis in eukaryotes 1.91 8.77e-3 52/108 (48.15%) NVL;NOP56;RRP7A;...
Renin secretion -1.93 3.34e-2 61/69 (88.41%) CALML3;CTSB;CALML4;...
Mineral absorption -2.08 0.00e+0 48/60 (80%) FTL;STEAP1;HEPH;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H