Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4UAPD)

Drug Name
Clemizole Drug Info
Synonyms
Clemizole; 442-52-4; Histacur; Clemizol; Histakool; Lergopenin; Clemizolum; Depocural; 1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole; 1-(4-Chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzo[d]imidazole; NSC 46261; UNII-T97CB3796L; CHEBI:52140; CJXAEXPPLWQRFR-UHFFFAOYSA-N; T97CB3796L; 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole; 1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-; 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole
Cross-matching ID
PubChem CID
2782
ChEBI ID
CHEMBL1407943
CAS Number
CAS 442-52-4
TTD Drug ID
D06XDJ
INTEDE Drug ID
DR2274

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.11 0.00e+0 34/36 (94.44%) MCM5;RFC4;RPA2;...
Fructose and mannose metabolism 2.08 0.00e+0 30/33 (90.91%) FBP1;PFKL;ALDOC;...
Mineral absorption 2.00 0.00e+0 48/60 (80%) HMOX1;MT1E;MT1F;...
Glycolysis / Gluconeogenesis 1.99 0.00e+0 56/67 (83.58%) FBP1;PFKL;PGK1;...
Arginine and proline metabolism 1.97 0.00e+0 39/50 (78%) AOC1;ODC1;ALDH4A1;...
Mismatch repair 1.93 1.78e-3 22/23 (95.65%) RFC4;RPA2;MSH2;...
Proteasome 1.91 4.57e-3 44/46 (95.65%) PSMC3;PSMD11;PSMB8;...
Pentose phosphate pathway 1.89 6.67e-3 25/30 (83.33%) FBP1;PFKL;ALDOC;...
Glutathione metabolism 1.86 9.48e-3 43/57 (75.44%) ODC1;GSTP1;GGCT;...
Galactose metabolism 1.82 1.17e-2 26/31 (83.87%) PFKL;MGAM;AKR1B10;...
Pyrimidine metabolism 1.79 1.55e-2 40/56 (71.43%) NME1;ENTPD1;RRM2;...
Glyoxylate and dicarboxylate metabolism 1.77 1.60e-2 23/30 (76.67%) ACAT2;DLD;GLDC;...
Citrate cycle (TCA cycle) 1.75 1.80e-2 30/30 (100%) DLD;MDH1;IDH2;...
TNF signaling pathway 1.74 2.36e-2 103/112 (91.96%) CXCL2;CXCL5;CREB1;...
Proximal tubule bicarbonate reclamation 1.74 2.28e-2 21/23 (91.3%) CA2;SLC4A4;MDH1;...
Ferroptosis 1.71 2.53e-2 36/41 (87.8%) HMOX1;SLC39A8;SAT1;...
IL-17 signaling pathway 1.71 2.57e-2 84/94 (89.36%) CXCL2;CXCL5;CXCL3;...
Nitrogen metabolism 1.70 2.73e-2 16/17 (94.12%) CA2;CA12;GLUL;...
Protein digestion and absorption 1.70 2.75e-2 78/103 (75.73%) SLC7A7;COL5A2;COL6A1;...
RNA degradation 1.68 3.25e-2 53/79 (67.09%) PFKL;LSM5;ENO1;...
Inflammatory bowel disease 1.67 3.30e-2 58/65 (89.23%) HLA-DRB1;IFNGR2;HLA-DRA;...
Rheumatoid arthritis 1.67 3.35e-2 78/93 (83.87%) CXCL2;CXCL5;CXCL3;...
One carbon pool by folate 1.65 3.80e-2 15/20 (75%) MTHFD1;SHMT1;GART;...
Amyotrophic lateral sclerosis 1.62 4.88e-2 267/364 (73.35%) CYCS;NUP85;TUBB2A;...
Dilated cardiomyopathy -1.81 4.04e-2 86/96 (89.58%) TPM2;ITGA2;ADCY1;...
Ovarian steroidogenesis -1.86 4.20e-2 41/51 (80.39%) PRKACA;CYP1A1;HSD3B1;...
Regulation of lipolysis in adipocytes -2.09 0.00e+0 52/55 (94.55%) AKT1;PIK3CD;PIK3CA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 6.66uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H