Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM4W9B3)

• Drug Name: Fosamprenavir Drug Info
• Synonyms: Telzir; Amprenavir phosphate; Fosamprenavir [INN]; GW 433908; GW433908; VX 175; Fosamprenavir (INN); Lexiva (TM); Lexiva (TN); Telzir (TN); Telzir(TM); VX-175; GW433908A (*Sodium Salt*); GW433908G (*Calcium Salt*); [(3S)-oxolan-3-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-1-phenyl-3-phosphonooxybutan-2-yl]carbamate; Carbamic acid, ((1S,2R)-3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)-, C-((3S)-tetrahydro-3-furanyl) ester; ((3S)Oxolan-3-yloxy)-N-((1S,2R)-3-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-1-benzyl-2-(phosphonooxy)propyl)carboxamide; (3-(((4-Aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)carbamic acid C-(tetrahydro-3-furanyl) ester
• Therapeutic Class: Anti-HIV Agents
• Cross-matching ID:
  PubChem CID: 131536
  ChEBI ID: CHEMBL82941
  CAS Number: CAS 226700-79-4
  TTD Drug ID: D0F5MT
  VARIDT Drug ID: DR01274
  INTEDE Drug ID: DR0745
  ACDINA Drug ID: D00292

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Renin-angiotensin system	1.90	7.88e-3	20/23 (86.96%)	AGTR1;ACE2;AGT;...
IL-17 signaling pathway	-1.86	3.03e-2	84/94 (89.36%)	PTGS2;HSP90AA1;ELAVL1;...
Ferroptosis	-2.29	0.00e+0	36/41 (87.8%)	VDAC3;CYBB;SLC3A2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲