Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM51TYR)

Drug Name
Esmolol Drug Info
Synonyms
ASL 8052-001; Brevibloc (TN); Esmolol (INN); Esmolol [INN:BAN]; Methyl p-[2-hydroxy-3-(isopropylamino)propoxy]hydrocinnamate; Methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate; Methyl 3-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]propanoate; Methyl 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate; Methyl 3-[4-({2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)phenyl]propanoate; Methyl 3-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}propanoate; Benzenepropanoic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, methyl ester; (+-)-Esmolol; (+-)-methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate
Therapeutic ClassAntihypertensive Agents
Cross-matching ID
PubChem CID
59768
ChEBI ID
CHEMBL768
CAS Number
CAS 81147-92-4
TTD Drug ID
D03XTC
VARIDT Drug ID
DR00853
INTEDE Drug ID
DR0626

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.14 0.00e+0 93/133 (69.92%) PPA1;NDUFB5;COX7C;...
DNA replication 1.94 1.45e-2 34/36 (94.44%) PCNA;MCM4;MCM6;...
IL-17 signaling pathway 1.92 1.61e-2 84/94 (89.36%) CXCL8;CXCL2;HSP90AA1;...
Parkinson disease 1.88 1.21e-2 176/249 (70.68%) GNAS;TUBB2A;NDUFB5;...
Ribosome 1.85 1.16e-2 113/158 (71.52%) MRPS16;RPL36;RPL14;...
Viral protein interaction with cytokine and cytokine re... 1.84 9.67e-3 84/100 (84%) CXCL8;CXCL2;CXCL14;...
Cell cycle 1.83 1.10e-2 110/124 (88.71%) CDC25B;PCNA;CHEK1;...
Mismatch repair 1.80 1.21e-2 22/23 (95.65%) PCNA;MSH2;MSH3;...
Coronavirus disease 1.77 1.72e-2 215/232 (92.67%) CXCL8;C7;MX2;...
Legionellosis 1.77 1.55e-2 51/57 (89.47%) CXCL8;CXCL2;HSPD1;...
Antigen processing and presentation 1.74 2.02e-2 60/78 (76.92%) HSP90AA1;HSPA8;CANX;...
Prion disease 1.72 2.34e-2 209/273 (76.56%) TUBB2A;C7;NDUFB5;...
Protein export 1.70 2.83e-2 17/23 (73.91%) SPCS1;SEC61G;SRPRB;...
Homologous recombination 1.70 2.62e-2 35/41 (85.37%) BARD1;RAD54B;RAD51;...
NOD-like receptor signaling pathway 1.66 3.67e-2 145/181 (80.11%) CXCL8;CXCL2;HSP90AA1;...
Alzheimer disease 1.65 3.81e-2 279/369 (75.61%) LPL;TUBB2A;FZD1;...
Thermogenesis 1.65 3.64e-2 173/232 (74.57%) GNAS;NDUFB5;COX7C;...
Pyruvate metabolism 1.65 3.60e-2 41/47 (87.23%) GLO1;ME2;ACAT2;...
Amyotrophic lateral sclerosis 1.63 3.87e-2 267/364 (73.35%) TUBB2A;NDUFB5;COX7C;...
Non-alcoholic fatty liver disease 1.62 4.06e-2 126/155 (81.29%) CXCL8;NDUFB5;CASP7;...
Bacterial invasion of epithelial cells -1.89 1.03e-2 59/77 (76.62%) PTK2;ITGB1;PIK3CB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 3.33uM 24H