Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM53BDW)

• Drug Name: Trioxsalen Drug Info
• Synonyms: trioxsalen; 3902-71-4; Trioxysalen; Trisoralen; Trimethylpsoralen; 4,5',8-Trimethylpsoralen; Elder 8011; Trioxysalenum; Trioxisaleno; Trioxysalene; 2',4,8-Trimethylpsoralen; 4,5',8-Trimethylpsoralene; NSC-71047; 2,5,9-Trimethyl-7H-furo[3,2-g]chromen-7-one; UNII-Y6UY8OV51T; Trioxysalene [INN-French]; Trioxysalenum [INN-Latin]; NSC71047; Trioxisaleno [INN-Spanish]; NSC 71047; TRIOXSALIN; 7H-Furo[3,2-g][1]benzopyran-7-one, 2,5,9-trimethyl-; EINECS 223-459-0; 4,8,5'-Trimethylpsoralen; BRN 0221723; Y6UY8OV51T
• Cross-matching ID:
  PubChem CID: 5585
  ChEBI ID: CHEMBL1475
  CAS Number: CAS 3902-71-4
  TTD Drug ID: D0FA2O

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	1.98	3.31e-2	34/36 (94.44%)	PCNA;RFC3;POLE2;...
Drug metabolism	1.84	4.97e-2	78/151 (51.66%)	CYP2E1;ALDH3A1;FMO3;...
Mannose type O-glycan biosynthesis	1.72	4.83e-2	14/23 (60.87%)	RXYLT1;B4GAT1;POMGNT1;...
Malaria	-1.80	3.54e-2	44/50 (88%)	TLR2;THBS2;GYPC;...
TNF signaling pathway	-1.80	4.13e-2	103/112 (91.96%)	BCL3;CCL20;IKBKG;...
Nicotinate and nicotinamide metabolism	-1.82	4.05e-2	25/35 (71.43%)	SIRT7;ENPP1;PNP;...
AMPK signaling pathway	-1.86	3.66e-2	106/120 (88.33%)	RAB8A;PPARGC1A;PRKAB2;...
Fatty acid biosynthesis	-1.88	4.50e-2	16/18 (88.89%)	ACACA;ACSL5;FASN;...
Circadian rhythm	-2.05	0.00e+0	26/31 (83.87%)	FBXW11;RORA;SKP1;...
Steroid biosynthesis	-2.30	0.00e+0	19/20 (95%)	SQLE;DHCR24;LSS;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼