Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM53SRA)

• Drug Name: Prochlorperazine Drug Info
• Synonyms: CHLOPERAZINE; Capazine; Chlormeprazine; Chlorperazine; Combid; Compazine; Compro; Emelent; Eskatrol; Kronocin; Meterazin; Meterazine; Nipodal; Novamin; Prochloroperazine; Prochlorpemazine; Prochlorperazin; Prochlorperazinum; Prochlorpermazine; Prochlorpromazine; Procloperazine; Proclorperazina; Proclorperazine; Stemetil; Tementil; Temetid; Vertigon; Compazine Suppositories; Prochlorperazine Edisylate Salt; Prochlorperazine dihydrobromide; Prochlorperazine dimaleate; Prochlorperazine maleate; Prochlorperazine mesilate; Bayer A 173; P77; RP 6140; SKF 4657; Buccastem (TN); Compazine (TN); Compro (TN); Phenotil (TN); Prochlorperazinum [INN-Latin]; Proclorperazina [INN-Spanish]; Stemetil (TN); Stemzine (TN); Compazine (*Maleate*); Prochlorperazine (JAN/USP/INN); Prochlorperazine [USAN:INN:BAN:JAN]; Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine; Chloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine [French]; N-(gamma-(4'-Methylpiperazinyl-1')propyl)-3-chlorophenothiazine; 2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine; 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-10H-phenothiazine; 2-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine; 2-Chloro-10-[3-(4-methyl-1-piper-azinyl)propyl]-10H-pheno-thiazine dimaleate; 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]-10H-phenothiazine; 2-chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine; 3-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine; 3-Chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazine; 6140 RP
• Therapeutic Class: Antipsychotic Agents
• Cross-matching ID:
  PubChem CID: 4917
  ChEBI ID: CHEMBL728
  CAS Number: CAS 58-38-8
  TTD Drug ID: D0B2UZ
  VARIDT Drug ID: DR00592
  INTEDE Drug ID: DR1345
  ACDINA Drug ID: D00559

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.53	0.00e+0	19/20 (95%)	MSMO1;SC5D;DHCR24;...
Glyoxylate and dicarboxylate metabolism	1.89	2.70e-2	23/30 (76.67%)	ACAT2;ACO1;SHMT1;...
Terpenoid backbone biosynthesis	1.78	4.20e-2	18/22 (81.82%)	HMGCS1;FDPS;ACAT2;...
Biosynthesis of unsaturated fatty acids	1.76	3.60e-2	21/27 (77.78%)	FADS1;SCD;FADS2;...
Caffeine metabolism	-1.66	4.98e-2	5/6 (83.33%)	CYP2A6;NAT2;NAT1
Salmonella infection	-1.67	4.87e-2	198/249 (79.52%)	DYNC2LI1;RIPK1;CASP1;...
Staphylococcus aureus infection	-1.70	4.31e-2	72/95 (75.79%)	C2;HLA-DRB1;DEFA6;...
Folate biosynthesis	-1.71	4.10e-2	23/26 (88.46%)	QDPR;CBR1;MOCS2;...
TNF signaling pathway	-1.71	4.51e-2	103/112 (91.96%)	AKT3;CREB1;CASP3;...
Diabetic cardiomyopathy	-1.73	4.40e-2	162/203 (79.8%)	COX7C;AKT3;NDUFS3;...
Non-alcoholic fatty liver disease	-1.73	4.54e-2	126/155 (81.29%)	MLX;COX7C;AKT3;...
Prion disease	-1.75	4.24e-2	209/273 (76.56%)	ATP5F1A;PPP3CC;SDHB;...
Amyotrophic lateral sclerosis	-1.79	3.48e-2	267/364 (73.35%)	ATXN2;ATP5F1A;PPP3CC;...
Thermogenesis	-1.86	1.76e-2	173/232 (74.57%)	SMARCA4;NDUFB1;ATP5F1A;...
Huntington disease	-1.87	1.65e-2	233/306 (76.14%)	ATP5F1A;SDHB;NDUFA4;...
Parkinson disease	-1.92	3.67e-3	176/249 (70.68%)	ATP5F1A;SDHB;NDUFA4;...
Oxidative phosphorylation	-2.10	0.00e+0	93/133 (69.92%)	COX15;NDUFB1;ATP5F1A;...
IL-17 signaling pathway	-2.19	0.00e+0	84/94 (89.36%)	CASP3;MUC5AC;NFKB1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼