Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM53ZGY)

• Drug Name: citral Drug Info
• Synonyms: geranial; geranialdehyde; citral a; trans-citral
• Cross-matching ID:
  PubChem CID: 638011
  ChEBI ID: CHEMBL16980
  CAS Number: CAS 5392-40-5
  TTD Drug ID: D00VWN

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Leukocyte transendothelial migration	1.92	3.89e-2	90/114 (78.95%)	ITGA4;PRKCB;CD99;...
DNA replication	1.86	4.38e-2	34/36 (94.44%)	PCNA;FEN1;POLE2;...
Other types of O-glycan biosynthesis	1.86	2.92e-2	29/47 (61.7%)	ST6GAL1;GALNT3;GALNT7;...
Renin-angiotensin system	1.83	2.92e-2	20/23 (86.96%)	CPA3;CTSG;AGT;...
Cytosolic DNA-sensing pathway	-1.69	4.40e-2	52/63 (82.54%)	CCL4;POLR3G;RELA;...
Phagosome	-1.70	4.63e-2	118/152 (77.63%)	MSR1;ATP6V0A2;TLR2;...
Cholesterol metabolism	-1.71	4.81e-2	44/50 (88%)	VDAC1;SOAT1;LCAT;...
Intestinal immune network for IgA production	-1.84	1.67e-2	38/48 (79.17%)	HLA-DMB;IL10;ICOS;...
Staphylococcus aureus infection	-1.85	1.77e-2	72/95 (75.79%)	HLA-DMB;IL10;MASP2;...
Type I diabetes mellitus	-1.89	6.87e-3	38/43 (88.37%)	HLA-DMB;HLA-DRB1;GZMB;...
Steroid hormone biosynthesis	-1.95	2.06e-3	43/61 (70.49%)	SULT2B1;HSD17B6;UGT2B28;...
Antigen processing and presentation	-2.03	0.00e+0	60/78 (76.92%)	TAPBP;HLA-DMB;HLA-DRB1;...
Graft-versus-host disease	-2.13	0.00e+0	32/42 (76.19%)	HLA-DMB;HLA-DRB1;GZMB;...
Allograft rejection	-2.27	0.00e+0	32/38 (84.21%)	HLA-DMB;IL10;HLA-DRB1;...
Autoimmune thyroid disease	-2.30	0.00e+0	46/53 (86.79%)	HLA-DMB;IL10;HLA-DRB1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.08uM - 40uM	3H, 24H	Hide ▲

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.08uM - 20uM	24H	Hide ▲