Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM54OKX)

Drug Name
Thenoyltrifluoroacetone Drug Info
Synonyms thenoyl trifluoro acetone; MolPort-001-660-116; STK312921; AKOS005437067; ST45092067; (2E)-1,1,1-trifluoro-4-oxo-4-(thiophen-2-yl)but-2-en-2-olate
Cross-matching ID
PubChem CID
5601
ChEBI ID
CHEMBL1236433
CAS Number
CAS 326-91-0
TTD Drug ID
D0F4QX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.00 0.00e+0 34/36 (94.44%) MCM2;RFC2;MCM3;...
Selenocompound metabolism -1.77 4.02e-2 11/17 (64.71%) TXNRD1;CTH;PAPSS2
Nicotinate and nicotinamide metabolism -1.85 1.68e-2 25/35 (71.43%) SIRT1;SIRT2;NMNAT2;...
Glycine, serine and threonine metabolism -1.87 2.10e-2 31/40 (77.5%) ALAS1;ALDH7A1;GLDC;...
Metabolism of xenobiotics by cytochrome P450 -1.97 6.99e-3 49/77 (63.64%) MGST2;CYP3A4;GSTA3;...
Steroid hormone biosynthesis -2.15 0.00e+0 43/61 (70.49%) HSD17B8;UGT2B28;STS;...
Steroid biosynthesis -2.26 0.00e+0 19/20 (95%) CYP51A1;EBP;SQLE;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Fibrocystic breast disease
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A (Parent) CVCL_0598 Homo sapiens 1.11uM - 10uM 3H, 6H, 12H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H