Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM56RAX)

• Drug Name: pentanoic acid Drug Info
• Synonyms: n-pentanoic acid; N-valeric acid; valeric acid; pentanoate
• Cross-matching ID:
  PubChem CID: 7991
  ChEBI ID: CHEMBL17418
  CAS Number: CAS 109-52-4
  TTD Drug ID: D0V6IE

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Synaptic vesicle cycle	2.14	0.00e+0	63/78 (80.77%)	SNAP25;ATP6V1D;SYT1;...
Collecting duct acid secretion	2.10	0.00e+0	22/27 (81.48%)	ATP6V1D;CA2;ATP6V0C;...
Phosphonate and phosphinate metabolism	-1.71	4.77e-2	5/6 (83.33%)	CHPT1
Pertussis	-1.71	4.75e-2	64/76 (84.21%)	C5;CD14;ITGB1;...
Renin-angiotensin system	-1.74	4.13e-2	20/23 (86.96%)	CPA3;LNPEP;REN;...
Complement and coagulation cascades	-1.77	3.84e-2	76/85 (89.41%)	VWF;CFD;C8A;...
Antigen processing and presentation	-1.78	4.48e-2	60/78 (76.92%)	CIITA;TAP2;HLA-DRB1;...
TGF-beta signaling pathway	-1.82	4.89e-2	81/94 (86.17%)	SMAD6;LEFTY1;GREM2;...
TNF signaling pathway	-1.96	3.67e-2	103/112 (91.96%)	CREB3L1;IRF1;CREB3L2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.04uM - 10uM	24H	Hide ▲