Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM57SVW)

Drug Name
benzamil Drug Info
Synonyms
Benzamil; 2898-76-2; UNII-04659UUJ94; N-(N-Benzylamidino)-3,5-diamino-6-chloropyrazine carboxamide; GNF-Pf-192; CHEMBL212579; CHEBI:34558; 04659UUJ94; 3,5-Diamino-6-chloro-N-(imino((phenylmethyl)amino)methyl)pyrazinecarboxamide; 3,5-diamino-N-(N'-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide; Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-(imino((phenylmethyl)amino)methyl)-; Spectrum3_001823; Prestwick1_000657; Prestwick3_000657; Prestwick2_000657; Prestwick0_000657; Lopac-B-2417; AC1L33CQ; Lopac0_000211; KBioGR_000300
Cross-matching ID
PubChem CID
108107
ChEBI ID
CHEMBL212579
CAS Number
CAS 2898-76-2
TTD Drug ID
D02ACL
VARIDT Drug ID
DR01348

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Neutrophil extracellular trap formation 1.93 1.33e-2 101/189 (53.44%) TLR4;PLCB1;RAC2;...
Endocrine and other factor-regulated calcium reabsorpti... 1.90 6.63e-3 49/53 (92.45%) PLCB1;GNAS;AP2M1;...
Pentose phosphate pathway 1.90 1.33e-2 25/30 (83.33%) G6PD;PGD;FBP1;...
Glycolysis / Gluconeogenesis 1.87 1.33e-2 56/67 (83.58%) ADH1B;PCK1;ENO1;...
Primary immunodeficiency 1.84 1.86e-2 33/38 (86.84%) IL2RG;ADA;AICDA;...
Metabolism of xenobiotics by cytochrome P450 1.82 1.77e-2 49/77 (63.64%) CYP1B1;GSTA4;AKR7A2;...
Glucagon signaling pathway 1.80 1.51e-2 89/107 (83.18%) PLCB1;GNAS;PCK1;...
Amoebiasis 1.78 1.66e-2 99/102 (97.06%) TLR4;PLCB1;GNAS;...
Allograft rejection 1.77 2.06e-2 32/38 (84.21%) HLA-B;HLA-A;HLA-DRB1;...
GnRH secretion 1.76 1.86e-2 60/64 (93.75%) PLCB1;PIK3R1;PLCB3;...
Notch signaling pathway 1.75 1.93e-2 49/59 (83.05%) JAG1;NOTCH3;CTBP2;...
Carbohydrate digestion and absorption 1.74 2.32e-2 37/47 (78.72%) PLCB1;PIK3R1;PLCB3;...
Valine, leucine and isoleucine degradation 1.74 2.14e-2 42/48 (87.5%) HMGCS1;ALDH3A2;ALDH2;...
Toll-like receptor signaling pathway 1.69 3.69e-2 94/104 (90.38%) TLR4;PIK3R1;RAC1;...
Base excision repair 1.68 4.33e-2 29/33 (87.88%) HMGB1;PARP2;NEIL3;...
Tryptophan metabolism 1.67 4.47e-2 35/42 (83.33%) KMO;CYP1B1;KYNU;...
Collecting duct acid secretion -1.83 2.46e-2 22/27 (81.48%) ATP6V1B1;ATP6V1G1;ATP6V0A1;...
Epithelial cell signaling in Helicobacter pylori infect... -1.90 1.17e-2 62/70 (88.57%) ATP6V1E1;ATP6AP1;MAPK14;...
Oxidative phosphorylation -2.19 0.00e+0 93/133 (69.92%) NDUFS4;ATP6V1H;ATP5PD;...
Mineral absorption -2.39 0.00e+0 48/60 (80%) MT2A;FTH1;HEPH;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 2.22uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 2.22uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 2.22uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 2.22uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 2.22uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H