Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM584TM)

• Drug Name: Butacaine Drug Info
• Synonyms: Butacaine sulfate; Butelline; Butyn; 149-15-5; Butacaine sulphate; Butacaine sulfate [USP]; UNII-PAU39W3CVB; EINECS 205-733-1; PAU39W3CVB; p-Aminobenzoyldibutylaminopropanol sulfate; Dibutylaminopropyl p-aminobenzoate sulfate; AI3-02405; 3'-Dibutylaminopropyl 4-aminobenzoate sulfate; 1-Propanol, 3-(dibutylamino)-, 4-aminobenzoate (ester), sulfate (2:1) (salt); 3-(p-Aminobenzoxy)-1-di-N-butylaminopropane sulfate; 3-(Dibutylamino)-1-propanol p-aminobenzoate (ester) sulfate (2:1)
• Cross-matching ID:
  PubChem CID: 2480
  ChEBI ID: CHEMBL129529
  CAS Number: CAS 149-16-6
  TTD Drug ID: D06ORU

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Toxoplasmosis	1.89	9.89e-3	103/112 (91.96%)	HLA-DQA1;HLA-DOB;LAMA2;...
Viral protein interaction with cytokine and cytokine re...	1.85	2.97e-2	84/100 (84%)	CXCL14;TNFSF10;CXCL10;...
Staphylococcus aureus infection	1.77	4.94e-2	72/95 (75.79%)	HLA-DQA1;KRT14;HLA-DOB;...
Mineral absorption	-1.84	2.70e-2	48/60 (80%)	ATP2B2;SLC31A1;STEAP1;...
Folate biosynthesis	-1.87	2.53e-2	23/26 (88.46%)	TH;ALPL;AKR1B10;...
Ribosome	-1.88	4.06e-2	113/158 (71.52%)	MRPL2;RPSA;RPS7;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲