Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM58PKG)

Drug Name
SB-213698 Drug Info
Synonyms TAN-67
Cross-matching ID
PubChem CID
9950038
ChEBI ID
CHEMBL327745
CAS Number
CAS 148545-09-9
TTD Drug ID
D08YUP

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Ribosome 1.87 2.51e-2 113/158 (71.52%) MRPS16;RPL36;MRPL34;...
Central carbon metabolism in cancer -1.65 4.89e-2 67/70 (95.71%) NTRK1;LDHC;FLT3;...
Arginine and proline metabolism -1.66 4.84e-2 39/50 (78%) SRM;CKMT2;GOT2;...
Arginine biosynthesis -1.66 4.94e-2 17/22 (77.27%) GOT2;ASL;GLS2;...
TGF-beta signaling pathway -1.68 4.38e-2 81/94 (86.17%) BMP8A;INHBC;RPS6KB1;...
Hypertrophic cardiomyopathy -1.68 4.65e-2 81/90 (90%) ITGB6;ITGA9;LAMA1;...
Valine, leucine and isoleucine degradation -1.69 4.47e-2 42/48 (87.5%) ACAA1;HIBCH;ALDH1B1;...
Porphyrin and chlorophyll metabolism -1.71 3.83e-2 23/43 (53.49%) BLVRA;HCCS;HEPH;...
Leishmaniasis -1.72 3.89e-2 67/77 (87.01%) TRAF6;NCF2;NFKBIA;...
Starch and sucrose metabolism -1.72 4.22e-2 25/36 (69.44%) GAA;G6PC2;AGL;...
p53 signaling pathway -1.73 4.06e-2 63/73 (86.3%) GADD45G;RCHY1;TP53;...
Cardiac muscle contraction -1.74 4.17e-2 64/87 (73.56%) CACNG1;CACNG2;COX7A2;...
Legionellosis -1.77 3.14e-2 51/57 (89.47%) RAB1A;NFKBIA;HSF1;...
Folate biosynthesis -1.78 3.16e-2 23/26 (88.46%) FPGS;QDPR;PTS;...
Leukocyte transendothelial migration -1.84 1.70e-2 90/114 (78.95%) RAP1A;PTPN11;RHOA;...
Neutrophil extracellular trap formation -1.88 1.99e-2 101/189 (53.44%) TLR2;FPR1;SELP;...
Pertussis -1.91 8.93e-3 64/76 (84.21%) JUN;C1QA;MAPK3;...
Ferroptosis -1.93 1.12e-2 36/41 (87.8%) ATG5;SLC3A2;GCLC;...
Bladder cancer -1.94 1.49e-2 40/41 (97.56%) TP53;HBEGF;MAPK3;...
Malaria -2.01 0.00e+0 44/50 (88%) ACKR1;THBS4;TLR2;...
Complement and coagulation cascades -2.02 0.00e+0 76/85 (89.41%) F12;C7;BDKRB1;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H