Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5A38V)

Drug Name
Metharbital Drug Info
Synonyms
Endiemal; Endiemalum; Gemonal; Gemonil; Gemonit; Metabarbital; Metarbital; Metarbitale; Methabarbital; Methabarbitone; Metharbitalum; Metharbitone; Metharbutal; Methylbarbital; Metarbitale [DCIT]; AN 23; Sch 412; Gemonil (TN); Metarbital [INN-Spanish]; Metharbital [INN:JAN]; Metharbitalum [INN-Latin]; N-Methylbarbital; Metharbital (JAN/INN); 1-Methylbarbital; 5,5-Diethyl-1-methyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5,5-Diethyl-1-methylbarbituric acid; 5,5-diethyl-1-methyl-1,3-diazinane-2,4,6-trione; 5,5-diethyl-1-methylpyrimidine-2,4,6(1H,3H,5H)-trione
Therapeutic ClassAnticonvulsants
Cross-matching ID
PubChem CID
4099
ChEBI ID
CHEMBL31827
CAS Number
CAS 50-11-3
TTD Drug ID
D02OZY

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.01 0.00e+0 34/36 (94.44%) PCNA;RFC4;MCM5;...
Spliceosome 2.00 0.00e+0 101/150 (67.33%) PRPF4;SNRPD2;SNRPB;...
Primary immunodeficiency 1.98 0.00e+0 33/38 (86.84%) CD3D;CD8A;IL7R;...
TGF-beta signaling pathway 1.89 8.19e-3 81/94 (86.17%) ID1;ID3;SMAD6;...
Mismatch repair 1.82 1.97e-2 22/23 (95.65%) PCNA;RFC4;RFC3;...
Taurine and hypotaurine metabolism -1.75 4.59e-2 8/11 (72.73%) GAD2;CDO1;GGT5;...
Legionellosis -1.88 9.17e-3 51/57 (89.47%) HBS1L;IL1B;SAR1A;...
Synaptic vesicle cycle -2.08 0.00e+0 63/78 (80.77%) DNM1;ATP6V0B;CLTC;...
Staphylococcus aureus infection -2.10 0.00e+0 72/95 (75.79%) CFH;PLG;KRT16;...
Complement and coagulation cascades -2.22 0.00e+0 76/85 (89.41%) C6;KNG1;C8A;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 24H