General Information of Drug (ID: DM5AOFW)

Drug Name
DIGITOXIGENIN Drug Info
Synonyms
Uzarigenin; 466-09-1; UNII-K9ZR7LI283; EINECS 207-373-0; NSC 119993; BRN 0095446; K9ZR7LI283; 3-beta-14-beta-5-Allo-cardenolid [German]; 3beta,14-Dihydroxy-5alpha-card-20(22)-enolide; 3-beta,14-Dihydroxy-5-alpha-card-20(22)-enolide; 4-18-00-01470 (Beilstein Handbook Reference); Urarigenin; Odorigeni; 3-beta-14-beta-5-Allo-cardenolid; AC1L3OS7; CHEMBL109863; SCHEMBL1152953; XZTUSOXSLKTKJQ-CIXPXFMPSA-N; MolPort-006-111-351; ZINC4073972; MCULE-2541512222; NCGC00384854-01; BC271971; 3,14-Dihydroxycard-20(22)-enolide #
Cross-matching ID
PubChem CID
4369270
ChEBI ID
CHEMBL1453
CAS Number
CAS 143-62-4
TTD Drug ID
D08ZNS
VARIDT Drug ID
DR01376

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
IL-17 signaling pathway 2.35 0.00e+0 84/94 (89.36%) CXCL8;FOSB;NFKBIA;...
TNF signaling pathway 2.34 0.00e+0 103/112 (91.96%) NFKBIA;FOS;CXCL2;...
Chronic myeloid leukemia 2.16 0.00e+0 72/76 (94.74%) GADD45B;NFKBIA;CDKN1A;...
FoxO signaling pathway 2.12 0.00e+0 118/131 (90.08%) GADD45B;CDKN1A;IL6;...
TGF-beta signaling pathway 2.10 0.00e+0 81/94 (86.17%) BMP2;THBS1;ID4;...
Bladder cancer 2.08 0.00e+0 40/41 (97.56%) CXCL8;THBS1;CDKN1A;...
Rheumatoid arthritis 2.06 0.00e+0 78/93 (83.87%) CXCL8;FOS;CXCL2;...
Epithelial cell signaling in Helicobacter pylori infect... 2.05 0.00e+0 62/70 (88.57%) CXCL8;NFKBIA;CXCL2;...
AGE-RAGE signaling pathway in diabetic complications 2.04 0.00e+0 97/100 (97%) CXCL8;EGR1;IL6;...
Kaposi sarcoma-associated herpesvirus infection 1.99 1.10e-3 172/193 (89.12%) CXCL8;NFKBIA;FOS;...
Endometrial cancer 1.96 3.00e-3 56/58 (96.55%) GADD45B;CDKN1A;GADD45A;...
Colorectal cancer 1.95 3.67e-3 84/86 (97.67%) GADD45B;AREG;FOS;...
Small cell lung cancer 1.91 5.08e-3 90/92 (97.83%) GADD45B;NFKBIA;PTGS2;...
NF-kappa B signaling pathway 1.90 4.72e-3 90/104 (86.54%) CXCL8;GADD45B;NFKBIA;...
Adherens junction 1.88 4.40e-3 63/71 (88.73%) INSR;SMAD3;ACTN4;...
NOD-like receptor signaling pathway 1.87 4.81e-3 145/181 (80.11%) CXCL8;NFKBIA;CXCL2;...
Prostate cancer 1.83 6.47e-3 93/97 (95.88%) NFKBIA;CDKN1A;GSTP1;...
Breast cancer 1.76 1.53e-2 119/147 (80.95%) GADD45B;FOS;CDKN1A;...
Cytosolic DNA-sensing pathway 1.75 1.80e-2 52/63 (82.54%) NFKBIA;IL6;NFKBIB;...
Basal cell carcinoma 1.75 1.76e-2 41/63 (65.08%) GADD45B;BMP2;CDKN1A;...
Malaria 1.74 1.94e-2 44/50 (88%) CXCL8;THBS1;IL6;...
PI3K-Akt signaling pathway 1.74 2.05e-2 317/354 (89.55%) AREG;NR4A1;THBS1;...
Cellular senescence 1.74 2.01e-2 139/156 (89.1%) CXCL8;GADD45B;CDKN1A;...
Hippo signaling pathway 1.73 1.93e-2 120/186 (64.52%) CCN2;AREG;BMP2;...
Thyroid cancer 1.73 1.85e-2 36/37 (97.3%) GADD45B;CDKN1A;GADD45A;...
Gastric cancer 1.72 2.07e-2 122/149 (81.88%) GADD45B;CDKN1A;GADD45A;...
B cell receptor signaling pathway 1.72 2.00e-2 71/81 (87.65%) NFKBIA;FOS;JUN;...
Hepatitis B 1.70 2.40e-2 151/162 (93.21%) CXCL8;NFKBIA;FOS;...
Pancreatic cancer 1.69 2.39e-2 75/76 (98.68%) GADD45B;CDKN1A;VEGFA;...
Epstein-Barr virus infection 1.69 2.31e-2 189/202 (93.56%) GADD45B;NFKBIA;TNFAIP3;...
ABC transporters -1.59 4.70e-2 37/45 (82.22%) ABCG1;ABCA8;ABCA12;...
Steroid hormone biosynthesis -1.60 4.41e-2 43/61 (70.49%) SRD5A1;AKR1C4;HSD3B1;...
Histidine metabolism -1.63 4.05e-2 16/22 (72.73%) ALDH1B1;ALDH3A2;AOC1;...
Propanoate metabolism -1.65 3.55e-2 30/34 (88.24%) DLD;HIBCH;PCCA;...
Metabolism of xenobiotics by cytochrome P450 -1.67 3.00e-2 49/77 (63.64%) UGT2B17;MGST2;GSTA1;...
Starch and sucrose metabolism -1.67 3.12e-2 25/36 (69.44%) GBA3;HKDC1;SI;...
Fanconi anemia pathway -1.68 3.26e-2 36/54 (66.67%) CENPX;FAAP100;FANCG;...
Citrate cycle (TCA cycle) -1.68 3.24e-2 30/30 (100%) SUCLG2;SDHB;ACLY;...
Mucin type O-glycan biosynthesis -1.69 3.08e-2 20/36 (55.56%) ST3GAL2;GALNT11;C1GALT1C1;...
Fatty acid degradation -1.71 2.98e-2 40/43 (93.02%) CPT1A;ALDH1B1;ALDH3A2;...
Arachidonic acid metabolism -1.71 3.22e-2 48/61 (78.69%) PTGS1;PTGIS;LTA4H;...
beta-Alanine metabolism -1.73 3.03e-2 25/30 (83.33%) HIBCH;ALDH1B1;ALDH3A2;...
Mismatch repair -1.76 2.07e-2 22/23 (95.65%) EXO1;POLD4;MSH3;...
Homologous recombination -1.81 1.20e-2 35/41 (85.37%) POLD4;RAD51D;RAD51;...
Ascorbate and aldarate metabolism -1.83 1.24e-2 15/30 (50%) ALDH1B1;AKR1A1;ALDH3A2;...
Amino sugar and nucleotide sugar metabolism -1.86 9.00e-3 38/48 (79.17%) GALE;HKDC1;GALT;...
Folate biosynthesis -1.89 6.00e-3 23/26 (88.46%) SPR;MOCOS;MOCS2;...
Pyruvate metabolism -1.89 7.20e-3 41/47 (87.23%) ADH6;GRHPR;ADH7;...
Glycolysis / Gluconeogenesis -1.95 2.25e-3 56/67 (83.58%) DLD;HK1;G6PC3;...
Pentose and glucuronate interconversions -1.96 3.00e-3 17/34 (50%) UGT2B17;UGT2B4;UGT2B15;...
Peroxisome -2.06 0.00e+0 72/82 (87.8%) PEX19;PEX6;MPV17;...
Porphyrin and chlorophyll metabolism -2.19 0.00e+0 23/43 (53.49%) ALAS1;PPOX;UGT2B17;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H