Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5D9YK)

Drug Name
CHOLINE Drug Info
Synonyms
choline; Choline ion; Bilineurine; Choline cation; Cholinum; 2-Hydroxy-N,N,N-trimethylethanaminium; 62-49-7; (2-Hydroxyethyl)trimethylammonium; trimethylethanolamine; N-trimethylethanolamine; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-; CCRIS 5847; UNII-N91BDP6H0X; AI3-24208; BRN 1736748; N,N,N-trimethylethanol-ammonium; CHEBI:15354; (beta-hydroxyethyl)trimethylammonium; EINECS 200-535-1; CHEMBL920; N91BDP6H0X; 2-hydroxyethyl(trimethyl)ammonium
Cross-matching ID
PubChem CID
305
ChEBI ID
CHEMBL920
CAS Number
CAS 62-49-7
TTD Drug ID
D08DAE
VARIDT Drug ID
DR00121
INTEDE Drug ID
DR0315

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Terpenoid backbone biosynthesis 1.91 9.46e-3 18/22 (81.82%) HMGCS1;HMGCS2;FDPS;...
PPAR signaling pathway 1.86 9.46e-3 66/74 (89.19%) PPARG;HMGCS1;ACAA1;...
Valine, leucine and isoleucine degradation 1.83 1.58e-2 42/48 (87.5%) HMGCS1;ACAA1;ABAT;...
Complement and coagulation cascades -1.83 4.98e-2 76/85 (89.41%) CFD;VWF;PLAU;...
Metabolism of xenobiotics by cytochrome P450 -1.97 3.49e-3 49/77 (63.64%) ADH1C;GSTA1;CYP2A6;...
Protein export -2.04 0.00e+0 17/23 (73.91%) SPCS1;SEC61A1;SRPRB;...
Porphyrin and chlorophyll metabolism -2.13 0.00e+0 23/43 (53.49%) UGT2B28;ALAS2;ALAS1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 1.25uM - 40uM 3H, 24H