Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5EKPM)

Drug Name
B-581 Drug Info
Synonyms
149759-96-6; B581; FTase Inhibitor I; B 581; B-581; CHEMBL91722; CHEBI:83620; N-[2(S)-(2(R)-2-Amino-3-mercaptopropylamino)-3-methylbutyl]-L-phenylalanyl-L-methionine trifluoroacetate salt; (S)-2-((S)-2-((S)-2-((R)-2-amino-3-mercaptopropylamino)-3-methylbutylamino)-3-phenylpropanamido)-4-(methylthio)butanoic acid; CBiol_001875; H-Cys-psi(CH2NH)Val-psi(CH2NH)Phe-Met-OH; AC1L31RF; BSPBio_001466; KBioSS_000186; KBioGR_000186; SCHEMBL2723960; KBio3_000372; KBio2_005322; KBio2_000186; KBio3_000371; KBio2_002754; CTK8E9094
Cross-matching ID
PubChem CID
132887
ChEBI ID
CHEMBL91722
CAS Number
CAS 149759-96-6
TTD Drug ID
D03GQH

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 1.89 1.49e-2 34/36 (94.44%) PCNA;POLA2;RPA3;...
Fanconi anemia pathway 1.82 3.72e-2 36/54 (66.67%) FANCL;REV1;RPA3;...
Ribosome biogenesis in eukaryotes 1.81 3.72e-2 52/108 (48.15%) HEATR1;XPO1;RPP38;...
Pyrimidine metabolism 1.74 4.83e-2 40/56 (71.43%) NME4;CDA;DPYD;...
Cell cycle 1.74 4.01e-2 110/124 (88.71%) SKP2;CDK1;PCNA;...
Malaria -1.64 4.01e-2 44/50 (88%) TLR2;TGFB1;CD81;...
Terpenoid backbone biosynthesis -1.66 3.72e-2 18/22 (81.82%) HMGCR;ACAT2;PMVK;...
Porphyrin and chlorophyll metabolism -1.67 3.46e-2 23/43 (53.49%) HCCS;BLVRA;PPOX;...
Tyrosine metabolism -1.67 3.44e-2 30/36 (83.33%) TAT;ADH6;FAH;...
Steroid hormone biosynthesis -1.69 3.21e-2 43/61 (70.49%) STS;CYP11B1;CYP3A7;...
Fatty acid degradation -1.69 3.41e-2 40/43 (93.02%) ADH6;ALDH2;ECI2;...
Ascorbate and aldarate metabolism -1.69 3.55e-2 15/30 (50%) RGN;UGT2B4;ALDH7A1;...
Glycolysis / Gluconeogenesis -1.71 3.10e-2 56/67 (83.58%) ADH6;BPGM;ALDH2;...
Mineral absorption -1.77 1.24e-2 48/60 (80%) SLC31A1;SLC39A4;ATP1A3;...
Synthesis and degradation of ketone bodies -1.78 1.24e-2 9/10 (90%) BDH1;BDH2;ACAT2;...
Arginine biosynthesis -1.80 1.13e-2 17/22 (77.27%) ARG1;GOT1;OTC;...
Steroid biosynthesis -1.85 9.91e-3 19/20 (95%) CYP27B1;FDFT1;HSD17B7;...
Arginine and proline metabolism -1.86 9.64e-3 39/50 (78%) P4HA2;ALDH4A1;PRODH;...
Pertussis -1.95 3.10e-3 64/76 (84.21%) MAPK1;NLRP3;C1QA;...
Glutathione metabolism -1.95 3.54e-3 43/57 (75.44%) GSR;G6PD;GPX2;...
Retinol metabolism -1.97 2.07e-3 41/68 (60.29%) CYP3A7;CYP2C8;PNPLA4;...
Ferroptosis -2.01 0.00e+0 36/41 (87.8%) SLC39A8;SLC3A2;FTH1;...
Leishmaniasis -2.01 0.00e+0 67/77 (87.01%) MAPK1;HLA-DOA;HLA-DQB1;...
Metabolism of xenobiotics by cytochrome P450 -2.04 0.00e+0 49/77 (63.64%) SULT2A1;GSTA3;EPHX1;...
Inflammatory bowel disease -2.09 0.00e+0 58/65 (89.23%) SMAD2;IL2RG;IL21;...
Pyruvate metabolism -2.10 0.00e+0 41/47 (87.23%) MDH2;ADH6;ACACA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
SK-ES-1 CVCL_0627 Homo sapiens 1.11uM - 10uM 24H
Brain
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 1.11uM - 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
MDA-MB-468 CVCL_0419 Homo sapiens 1.11uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
T-47D CVCL_0553 Homo sapiens 1.11uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
SNU-407 CVCL_5004 Homo sapiens 1.11uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 1.11uM - 10uM 24H
HEC-1-A CVCL_0293 Homo sapiens 1.11uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 1.11uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 1.11uM - 10uM 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 1.11uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 1.11uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
NCI-H1573 CVCL_1483 Homo sapiens 1.11uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 1.11uM - 10uM 24H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 1.11uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 1.11uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
NCI-H2110 CVCL_1529 Homo sapiens 1.11uM - 10uM 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 1.11uM - 10uM 24H
Ovary
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OVTOKO CVCL_3114 Homo sapiens 1.11uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 1.11uM - 10uM 24H
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H
IGR-37 CVCL_1303 Homo sapiens 1.11uM - 10uM 24H
Mel-HO CVCL_1402 Homo sapiens 1.11uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 1.11uM - 10uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 1.11uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 1.11uM - 10uM 24H