Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5FL14)

Drug Name
Amifostine Drug Info
Synonyms Ethiofos; Ethyol; Gammaphos; WR-1064; WR-2721; WR-2721C; YM-08310
Cross-matching ID
PubChem CID
2141
ChEBI ID
CHEMBL1006
CAS Number
CAS 20537-88-6
TTD Drug ID
D06CIE
INTEDE Drug ID
DR0085

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Fanconi anemia pathway 1.87 3.65e-2 36/54 (66.67%) REV3L;BRCA1;PALB2;...
Base excision repair 1.86 2.66e-2 29/33 (87.88%) POLE2;PARP2;NTHL1;...
Pyrimidine metabolism 1.85 1.99e-2 40/56 (71.43%) UMPS;DCTPP1;ENPP1;...
DNA replication 1.80 1.99e-2 34/36 (94.44%) MCM6;POLE2;PRIM1;...
Protein export -1.64 4.38e-2 17/23 (73.91%) SRPRA;SPCS3;SRP54;...
Epithelial cell signaling in Helicobacter pylori infect... -1.64 4.57e-2 62/70 (88.57%) TCIRG1;IKBKB;F11R;...
Aldosterone-regulated sodium reabsorption -1.65 4.16e-2 34/37 (91.89%) NR3C2;PRKCA;INSR;...
Inflammatory bowel disease -1.66 3.65e-2 58/65 (89.23%) NFKB1;TGFB2;HLA-DPA1;...
Arginine and proline metabolism -1.68 3.40e-2 39/50 (78%) CKB;GOT1;ALDH4A1;...
Histidine metabolism -1.69 2.87e-2 16/22 (72.73%) ALDH2;ALDH9A1;ASPA;...
Amoebiasis -1.70 3.02e-2 99/102 (97.06%) C8B;RAB5B;GNA15;...
Pertussis -1.71 2.83e-2 64/76 (84.21%) C1QA;RHOA;TNF;...
Glyoxylate and dicarboxylate metabolism -1.72 2.92e-2 23/30 (76.67%) MDH2;SHMT2;ACO2;...
Leishmaniasis -1.72 2.95e-2 67/77 (87.01%) FCGR3B;HLA-DPB1;TNF;...
Necroptosis -1.72 3.14e-2 113/159 (71.07%) SHARPIN;GLUD2;FADD;...
Intestinal immune network for IgA production -1.72 3.37e-2 38/48 (79.17%) ICOS;CCL25;TNFRSF17;...
Pyruvate metabolism -1.73 3.24e-2 41/47 (87.23%) ADH1B;AKR1A1;PKM;...
Vibrio cholerae infection -1.73 3.40e-2 44/50 (88%) PRKCA;ATP6V1C1;ADCY3;...
Ferroptosis -1.75 3.01e-2 36/41 (87.8%) FTL;VDAC2;SLC7A11;...
Citrate cycle (TCA cycle) -1.75 3.31e-2 30/30 (100%) IDH1;MDH2;SDHA;...
Tryptophan metabolism -1.78 2.83e-2 35/42 (83.33%) CYP1B1;IDO1;ALDH2;...
Rheumatoid arthritis -1.81 2.55e-2 78/93 (83.87%) ATP6V0A4;ACP5;ATP6V1A;...
Glycine, serine and threonine metabolism -1.82 2.37e-2 31/40 (77.5%) SHMT2;BPGM;CTH;...
Lysosome -1.82 2.76e-2 115/128 (89.84%) HYAL3;CTSV;GNS;...
Systemic lupus erythematosus -1.82 3.31e-2 45/135 (33.33%) FCGR2A;HLA-DPA1;CD80;...
Protein processing in endoplasmic reticulum -1.85 2.87e-2 127/171 (74.27%) OS9;PREB;YOD1;...
Valine, leucine and isoleucine degradation -1.87 3.82e-2 42/48 (87.5%) ALDH2;ALDH9A1;HIBCH;...
Mineral absorption -1.91 3.82e-2 48/60 (80%) SLC30A1;ATP2B1;MT1G;...
Legionellosis -1.96 3.82e-2 51/57 (89.47%) NFKBIA;VCP;SAR1B;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.002uM - 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 15uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.002uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.002uM - 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.002uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H