Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5FLTY)

• Drug Name: Risedronate Drug Info
• Synonyms: Risedronic acid; 105462-24-6; Actonel; Atelvia; Acido risedronico; Acidum risedronicum; Benet; Risedronic acid [INN:BAN]; Acidum risedronicum [INN-Latin]; Acido risedronico [INN-Spanish]; Acide risedronique [INN-French]; Risedronic acid monohydrate; NE-58095; UNII-KM2Z91756Z; C7H11NO7P2; NE 58019; HSDB 7326; [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid; (1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonic acid; Risedronic acid (Actonel); CHEMBL923; CHEBI:8869; Phosphonic acid,; Benet; RIS; Ridron; Acide risedronique; Bisphosphonate 1; Actonel (TN); Ridron (TN); Risedronic acid (INN); (1-Hydroxy-2-(3-pyridyl)ethylidene)diphosphonic acid; (1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphonic acid; (1-hydroxy-2-pyridin-3-ylethane-1,1-diyl)bis(phosphonic acid); 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID
• Therapeutic Class: Bone Density Conservation Agents
• Cross-matching ID:
  PubChem CID: 5245
  ChEBI ID: CHEMBL923
  CAS Number: CAS 105462-24-6
  TTD Drug ID: D0PA5S
  ACDINA Drug ID: D00598

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Proximal tubule bicarbonate reclamation	1.92	4.01e-2	21/23 (91.3%)	SLC4A4;PCK1;FXYD2;...
Steroid biosynthesis	1.89	2.50e-2	19/20 (95%)	MSMO1;DHCR7;NSDHL;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	12uM	72H	Hide ▲