Details of the Drug Pharmacogenomic Perturbation Atlas

Glimepiride Drug Info

Amarel; Amaryl; Endial; Glimepirid; Glimepirida; Glimepiridum; Glimepride; Glimer; Glymepirid; Roname; Solosa; Glimepirida [Spanish]; Glimepiridum [Latin]; Sandoz glimepiride; HOE 490; Amaryl (TN); Hoe-490; Novo-glimepiride; PMS-glimepiride; Ratio-glimepiride; Amaryl, Glista OD, Glimepiride; Glimepiride [USAN:BAN:INN]; Glimepiride (JAN/USP/INN); 1-((p-(2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl)phenyl)sulfonyl)-3-(trans-4-methylcyclohexyl)urea; 1-{[4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]amino}ethyl)phenyl]sulfonyl}-3-(trans-4-methylcyclohexyl)urea; 3-ethyl-4-methyl-N-[2-(4-{[(trans-4-methylcyclohexyl)carbamoyl]sulfamoyl}phenyl)ethyl]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide; 3-ethyl-4-methyl-n-(4-(n-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-oxo-2,5-dihydro; 4-ethyl-3-methyl-N-[2-[4-[(4-methylcyclohexyl)carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide; 64598P

Therapeutic Class

Hypoglycemic Agents

Cross-matching ID

PubChem CID

3476

ChEBI ID

CHEMBL5383

CAS Number

CAS 261361-60-8

TTD Drug ID

D0B2GI

VARIDT Drug ID

DR00158

INTEDE Drug ID

DR0777

ACDINA Drug ID

D00302

General Information of Drug (ID: DM5FSJA)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
IL-17 signaling pathway	2.10	0.00e+0	84/94 (89.36%)	S100A7;S100A8;MMP9;...
Glycolysis / Gluconeogenesis	2.09	0.00e+0	56/67 (83.58%)	DLD;PGAM1;GAPDH;...
DNA replication	1.86	0.00e+0	34/36 (94.44%)	PCNA;MCM2;MCM4;...
Allograft rejection	1.81	1.47e-2	32/38 (84.21%)	HLA-DQA1;HLA-DRB1;HLA-B;...
Cell cycle	1.79	2.83e-2	110/124 (88.71%)	CCNB1;PCNA;CCNA2;...
Central carbon metabolism in cancer	1.78	2.36e-2	67/70 (95.71%)	PGAM1;PDGFRA;GLS;...
p53 signaling pathway	1.76	2.53e-2	63/73 (86.3%)	CCNB1;CYCS;THBS1;...
Intestinal immune network for IgA production	1.75	2.80e-2	38/48 (79.17%)	CXCL12;HLA-DQA1;HLA-DRB1;...
Human T-cell leukemia virus 1 infection	1.74	3.14e-2	197/219 (89.95%)	HLA-DQA1;CCNA2;NRP1;...
Cellular senescence	1.73	3.18e-2	139/156 (89.1%)	CCNB1;CCNA2;PIK3CD;...
MicroRNAs in cancer	1.73	3.43e-2	146/310 (47.1%)	MMP9;TIMP3;MARCKS;...
Rheumatoid arthritis	1.70	4.03e-2	78/93 (83.87%)	CXCL1;CXCL12;HLA-DQA1;...
Progesterone-mediated oocyte maturation	1.70	3.81e-2	75/100 (75%)	CCNB1;CCNA2;PIK3CD;...
Staphylococcus aureus infection	1.68	4.38e-2	72/95 (75.79%)	KRT15;KRT14;KRT23;...
Arachidonic acid metabolism	-1.89	0.00e+0	48/61 (78.69%)	PLA2G10;GPX7;PTGS1;...
Peroxisome	-1.91	0.00e+0	72/82 (87.8%)	PHYH;AGPS;SLC27A2;...
Other glycan degradation	-1.93	0.00e+0	13/18 (72.22%)	HEXB;HEXA;MAN2C1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	6.66uM	72H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H

Peripheral blood

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H