Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5H2W9)

• Drug Name: dioscin Drug Info
• Synonyms: Dioscin; 19057-60-4; Collettiside III; Dioscine; CHEBI:74023; CCRIS 4123; UNII-3B95U4OLWV; 3-O-(Rhaalpha1-4(Rhaalpha1-2)Glcbeta)-(25R)-spirost-5-en-3beta-ol; 3-O-[alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc]-diosgenin; 3-O-[alpha-L-Rhap-(1->4)-[alpha-L-Rhap-(1->2)]-beta-D-Glcp]-diosgenin; (25R)-spirost-5-en-3beta-yl alpha-L-rhamnopyranosyl-(1->2)-[alpha-L-mannopyranosyl-(1->4)]-beta-D-glucopyranoside; 3B95U4OLWV; AC1L3OGN; Dioscin(Collettiside III); Dioscin (Collettiside III); GTPL840
• Cross-matching ID:
  PubChem CID: 119245
  ChEBI ID: CHEMBL74023
  CAS Number: CAS 19057-60-4
  TTD Drug ID: D0F2AD
  VARIDT Drug ID: DR00897

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Synaptic vesicle cycle	2.13	1.19e-2	63/78 (80.77%)	SNAP25;SYT1;TCIRG1;...
Yersinia infection	1.96	2.96e-2	120/137 (87.59%)	FYB1;LCP2;ELMO1;...
Neutrophil extracellular trap formation	1.90	3.56e-2	101/189 (53.44%)	CYBB;PRKCA;ITGAM;...
Fructose and mannose metabolism	1.87	3.26e-2	30/33 (90.91%)	ALDOC;PFKP;HK1;...
Nicotine addiction	1.80	4.51e-2	32/40 (80%)	SLC17A7;GABRE;GABRG2;...
IL-17 signaling pathway	1.80	4.15e-2	84/94 (89.36%)	LCN2;S100A9;S100A8;...
Fc gamma R-mediated phagocytosis	1.78	4.74e-2	79/97 (81.44%)	PAK1;PRKCA;ARPC1B;...
DNA replication	-1.86	1.69e-2	34/36 (94.44%)	LIG1;POLD2;RFC1;...
Cardiac muscle contraction	-1.96	8.44e-3	64/87 (73.56%)	ATP1A2;MYH7;CYC1;...
Nucleotide excision repair	-2.08	8.44e-3	40/47 (85.11%)	CCNH;POLD1;RBX1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲