General Information of Drug (ID: DM5IA9W)

Drug Name
droxinostat Drug Info
Synonyms NS-41080; NS41080
Cross-matching ID
PubChem CID
568416
ChEBI ID
CHEMBL1526649
CAS Number
CAS 99873-43-5
TTD Drug ID
D00VXM

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Galactose metabolism 2.13 0.00e+0 26/31 (83.87%) AKR1B10;UGP2;SI;...
Bacterial invasion of epithelial cells 2.09 0.00e+0 59/77 (76.62%) CDH1;CAV2;FN1;...
Steroid biosynthesis 2.01 4.48e-3 19/20 (95%) SC5D;LIPA;DHCR7;...
Aldosterone-regulated sodium reabsorption 1.93 3.36e-3 34/37 (91.89%) SCNN1A;PRKCB;PRKCA;...
Tight junction 1.86 1.61e-2 130/169 (76.92%) CLDN10;PRKACB;MYH10;...
Sulfur metabolism 1.85 1.34e-2 9/10 (90%) PAPSS1;SUOX;ETHE1;...
Regulation of lipolysis in adipocytes 1.83 1.15e-2 52/55 (94.55%) PRKACB;GNAI2;PLAAT3;...
Biosynthesis of unsaturated fatty acids 1.80 1.85e-2 21/27 (77.78%) ACOT7;ELOVL6;ELOVL5;...
Endocytosis 1.79 1.79e-2 198/252 (78.57%) HSPA1A;TGFBR2;PDGFRA;...
Gap junction 1.79 1.61e-2 72/88 (81.82%) PRKACB;GNAI2;PRKCB;...
Endocrine and other factor-regulated calcium reabsorpti... 1.79 1.71e-2 49/53 (92.45%) PRKACB;PRKCB;ATP2B4;...
Vibrio cholerae infection 1.78 1.79e-2 44/50 (88%) PRKACB;GNAS;ATP6V1A;...
Glycerophospholipid metabolism 1.77 1.65e-2 71/98 (72.45%) GPD1L;PLAAT3;PLA2G15;...
Citrate cycle (TCA cycle) 1.75 2.21e-2 30/30 (100%) ACO1;IDH1;DLD;...
Fat digestion and absorption 1.74 2.24e-2 35/43 (81.4%) APOA4;AGPAT2;ABCA1;...
Fatty acid elongation 1.72 2.60e-2 19/27 (70.37%) ACOT7;ELOVL6;ELOVL5;...
Adherens junction 1.70 2.84e-2 63/71 (88.73%) TCF7L2;TGFBR2;CDH1;...
Glyoxylate and dicarboxylate metabolism 1.70 2.98e-2 23/30 (76.67%) ACO1;DLD;PCCA;...
Glutathione metabolism 1.69 3.53e-2 43/57 (75.44%) G6PD;PGD;IDH1;...
Synaptic vesicle cycle 1.68 3.63e-2 63/78 (80.77%) SLC1A1;STXBP1;ATP6V1A;...
Glycerolipid metabolism 1.67 3.84e-2 44/61 (72.13%) AKR1B10;DGKA;MBOAT2;...
Pentose phosphate pathway 1.67 3.66e-2 25/30 (83.33%) G6PD;PGD;ALDOC;...
Leukocyte transendothelial migration 1.65 3.97e-2 90/114 (78.95%) CLDN10;GNAI2;PRKCB;...
Carbohydrate digestion and absorption 1.61 4.84e-2 37/47 (78.72%) PRKCB;SI;HK1;...
Inflammatory bowel disease -1.62 4.52e-2 58/65 (89.23%) IL18;IL12B;HLA-DRA;...
Viral myocarditis -1.64 4.27e-2 53/60 (88.33%) ITGB2;CD80;ITGAL;...
Graft-versus-host disease -1.65 4.25e-2 32/42 (76.19%) KLRD1;CD28;CD80;...
Toll-like receptor signaling pathway -1.65 4.68e-2 94/104 (90.38%) TLR7;CCL4;CD40;...
Viral protein interaction with cytokine and cytokine re... -1.66 4.50e-2 84/100 (84%) CCL13;CCR5;PPBP;...
Herpes simplex virus 1 infection -1.67 4.66e-2 165/498 (33.13%) HLA-DRA;HCFC1;HLA-B;...
Circadian rhythm -1.70 4.06e-2 26/31 (83.87%) PRKAB2;PRKAG1;PRKAB1;...
Type I diabetes mellitus -1.74 3.16e-2 38/43 (88.37%) CD28;CD80;LTA;...
Cytosolic DNA-sensing pathway -1.75 3.29e-2 52/63 (82.54%) POLR1C;IKBKB;IL18;...
Intestinal immune network for IgA production -1.86 1.42e-2 38/48 (79.17%) HLA-DRA;CXCL12;ICOSLG;...
One carbon pool by folate -1.89 1.26e-2 15/20 (75%) AMT;MTHFD2;GART;...
Allograft rejection -1.94 1.26e-2 32/38 (84.21%) IL12B;HLA-DRA;HLA-B;...
Autoimmune thyroid disease -2.02 6.32e-3 46/53 (86.79%) CD28;CD80;HLA-DMB;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H