Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5KNMD)

Drug Name
spiramide Drug Info
Synonyms AMI-193; R-5808
Cross-matching ID
PubChem CID
68186
ChEBI ID
CHEMBL79834
CAS Number
CAS 510-74-7
TTD Drug ID
D0V5SQ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.47 0.00e+0 127/171 (74.27%) HERPUD1;HYOU1;SEC24D;...
Steroid biosynthesis 2.39 0.00e+0 19/20 (95%) NSDHL;MSMO1;SQLE;...
Protein export 2.15 0.00e+0 17/23 (73.91%) SEC63;SRPRB;SPCS3;...
Folate biosynthesis 2.00 1.55e-3 23/26 (88.46%) AKR1C3;PTS;AKR1B10;...
Terpenoid backbone biosynthesis 1.98 1.24e-3 18/22 (81.82%) HMGCS1;IDI1;HMGCR;...
Steroid hormone biosynthesis 1.84 1.55e-2 43/61 (70.49%) AKR1C1;AKR1C3;AKR1C2;...
Mitophagy 1.75 2.74e-2 56/68 (82.35%) EIF2AK3;CITED2;CALCOCO2;...
N-Glycan biosynthesis 1.70 3.94e-2 38/50 (76%) DAD1;ALG5;MGAT2;...
Biosynthesis of unsaturated fatty acids 1.68 4.40e-2 21/27 (77.78%) SCD;FADS1;ELOVL6;...
Vibrio cholerae infection 1.67 4.27e-2 44/50 (88%) SEC61B;KDELR3;SEC61A1;...
Amino sugar and nucleotide sugar metabolism 1.66 4.55e-2 38/48 (79.17%) GFPT1;NANS;PGM3;...
Rap1 signaling pathway -1.71 3.59e-2 184/210 (87.62%) FLT1;VEGFD;MAPK1;...
Autoimmune thyroid disease -1.73 3.37e-2 46/53 (86.79%) CGA;IFNA16;HLA-DOA;...
Platelet activation -1.75 3.27e-2 106/124 (85.48%) MAPK1;PTGS1;F2;...
Vascular smooth muscle contraction -1.76 3.13e-2 113/133 (84.96%) EDN1;PPP1CC;GNAQ;...
Bacterial invasion of epithelial cells -1.76 3.53e-2 59/77 (76.62%) ARPC2;RAC1;ARHGEF26;...
DNA replication -1.76 4.03e-2 34/36 (94.44%) MCM6;RFC2;POLE;...
Regulation of actin cytoskeleton -1.79 2.72e-2 185/218 (84.86%) MAPK1;F2;ITGAV;...
Allograft rejection -1.79 3.27e-2 32/38 (84.21%) HLA-C;HLA-DRA;HLA-DQB1;...
Focal adhesion -1.79 4.08e-2 180/201 (89.55%) SHC3;MYLK3;COL6A3;...
Graft-versus-host disease -1.81 3.46e-2 32/42 (76.19%) HLA-DOA;KIR2DL1;KIR2DL3;...
Mineral absorption -1.82 3.71e-2 48/60 (80%) MT1M;ATP1A1;ATOX1;...
Cell cycle -1.88 4.45e-2 110/124 (88.71%) CDC7;CCNE1;EP300;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 2.5uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 2.5uM - 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H