Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5L6HI)

Drug Name
Atomoxetine Drug Info
Synonyms
Tomoxetina; Tomoxetine; Tomoxetinum; Tomoxetina [Spanish]; Tomoxetine [INN]; Tomoxetinum [Latin]; Atomoxetine (INN); Attentin (TN); Strattera (TN); Tomoxetin (TN); (-)-Tomoxetine; (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine
Cross-matching ID
PubChem CID
54841
ChEBI ID
CHEMBL641
CAS Number
CAS 83015-26-3
TTD Drug ID
D04CRN
VARIDT Drug ID
DR00393
INTEDE Drug ID
DR0153
ACDINA Drug ID
D00049

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.44 0.00e+0 93/133 (69.92%) ATP6V1D;COX5B;ATP5MG;...
Parkinson disease 2.21 0.00e+0 176/249 (70.68%) DAXX;UCHL1;CYCS;...
Diabetic cardiomyopathy 2.19 0.00e+0 162/203 (79.8%) GAPDH;CYBA;TGFBR2;...
Ribosome 2.14 0.00e+0 113/158 (71.52%) RPL36;MRPS16;RPS5;...
Huntington disease 2.14 0.00e+0 233/306 (76.14%) CYCS;COX5B;PSMB3;...
Amyotrophic lateral sclerosis 2.07 0.00e+0 267/364 (73.35%) DAXX;CYCS;COX5B;...
Non-alcoholic fatty liver disease 2.01 0.00e+0 126/155 (81.29%) CYCS;COX5B;CXCL8;...
DNA replication 2.00 0.00e+0 34/36 (94.44%) RPA3;POLD2;POLE2;...
RNA degradation 1.90 2.22e-3 53/79 (67.09%) LSM5;PFKL;CNOT4;...
Prion disease 1.89 2.00e-3 209/273 (76.56%) CYBA;CYCS;COX5B;...
Alzheimer disease 1.80 1.18e-2 279/369 (75.61%) GAPDH;CYCS;COX5B;...
Thermogenesis 1.77 1.83e-2 173/232 (74.57%) COX5B;ATP5MG;NDUFA4;...
Fc gamma R-mediated phagocytosis 1.71 3.38e-2 79/97 (81.44%) MARCKSL1;GSN;PLCG2;...
Autoimmune thyroid disease 1.70 4.28e-2 46/53 (86.79%) HLA-B;HLA-DPB1;HLA-G;...
Ascorbate and aldarate metabolism -1.98 1.00e-2 15/30 (50%) UGT2A3;ALDH1B1;UGT2B17;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.04uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H