Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5LRKC)

• Drug Name: L-368899 Drug Info
• Synonyms: UNII-ER33G946JT; L-368899; ER33G946JT; CHEMBL1253853; L 368,899; L 368899; 148927-60-0; (S)-2-amino-N-((1S,2S,4R)-7,7-dimethyl-1-((4-o-tolylpiperazin-1-ylsulfonyl)methyl)bicyclo[2.2.1]heptan-2-yl)-4-(methylsulfonyl)butanamide; GTPL2249; SCHEMBL17423276; ZINC3923061; BDBM50326719; NCGC00485193-01; 1-(((7,7-Dimethyl-2-(2-amino-4-(methylsulfonyl)butyramido)bicyclo(2.2.1)heptan-1-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine; Butanamide, 2-amino-N-(7,7-dimethyl-1-(((4-(2-methylphenyl)-1-piperazinyl)sulfonyl)methyl)bicyclo
• Cross-matching ID:
  PubChem CID: 9872389
  ChEBI ID: CHEMBL1253853
  CAS Number: CAS 148927-60-0
  TTD Drug ID: D0Q8RX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	2.48	0.00e+0	19/20 (95%)	DHCR24;MSMO1;DHCR7;...
Valine, leucine and isoleucine degradation	2.17	0.00e+0	42/48 (87.5%)	HMGCS1;ACAT2;MCCC2;...
Terpenoid backbone biosynthesis	2.06	2.84e-3	18/22 (81.82%)	HMGCS1;IDI1;FDPS;...
Biosynthesis of unsaturated fatty acids	2.00	4.26e-3	21/27 (77.78%)	SCD;FADS1;FADS2;...
Cell cycle	1.79	3.75e-2	110/124 (88.71%)	CHEK1;PRKDC;PCNA;...
Synthesis and degradation of ketone bodies	1.77	3.98e-2	9/10 (90%)	HMGCS1;ACAT2;OXCT1
Mismatch repair	1.69	4.92e-2	22/23 (95.65%)	PCNA;RFC2;POLD2;...
Butanoate metabolism	1.69	4.52e-2	23/28 (82.14%)	HMGCS1;ACAT2;AACS;...
Propanoate metabolism	1.67	4.80e-2	30/34 (88.24%)	ACAT2;HIBCH;DLD;...
Proximal tubule bicarbonate reclamation	-1.67	4.64e-2	21/23 (91.3%)	CA2;FXYD2;SLC4A4;...
Transcriptional misregulation in cancer	-1.67	4.93e-2	158/192 (82.29%)	ETV5;ASPSCR1;MEIS1;...
Type I diabetes mellitus	-1.69	4.35e-2	38/43 (88.37%)	CD80;IL1A;HLA-DPA1;...
Graft-versus-host disease	-1.71	3.76e-2	32/42 (76.19%)	CD80;IL1A;HLA-DPA1;...
Phagosome	-1.73	3.41e-2	118/152 (77.63%)	M6PR;ATP6V0C;CYBB;...
Intestinal immune network for IgA production	-1.74	3.84e-2	38/48 (79.17%)	CCL25;IL5;CD40;...
Inflammatory bowel disease	-1.76	3.25e-2	58/65 (89.23%)	TLR5;NFKB1;IL23A;...
Retinol metabolism	-1.76	3.60e-2	41/68 (60.29%)	ADH6;ADH1A;DHRS9;...
Allograft rejection	-1.80	3.19e-2	32/38 (84.21%)	HLA-DOB;IFNG;IL10;...
Leishmaniasis	-1.82	3.13e-2	67/77 (87.01%)	CR1;NCF4;IL1A;...
Neutrophil extracellular trap formation	-1.82	3.79e-2	101/189 (53.44%)	RAC2;MAPK1;SIGLEC9;...
Asthma	-1.84	4.55e-2	25/31 (80.65%)	IL5;CD40;IL13;...
Hematopoietic cell lineage	-2.22	0.00e+0	90/99 (90.91%)	CSF2RA;CD2;CD1A;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H, 24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	10uM	6H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H	Show ▼