Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5LU3N)

Drug Name
Selamectin Drug Info
Synonyms
selamectin; UNII-A2669OWX9N; A2669OWX9N; UK-124,114; 25-cyclohexyl-25-de(1-methylpropyl)-5-deoxy-22 23-dihydro-5-(hydroxyimino)-avermectin B1 monosaccharide; Stronghold; Revolution; 220119-17-5; 25-Cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-avermectin A1a
Cross-matching ID
PubChem CID
9578507
ChEBI ID
CHEMBL1908325
CAS Number
CAS 165108-07-6
VARIDT Drug ID
DR01584

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein processing in endoplasmic reticulum 2.19 0.00e+0 127/171 (74.27%) ATF4;HERPUD1;HSPA6;...
Amino sugar and nucleotide sugar metabolism 1.91 5.74e-3 38/48 (79.17%) GFPT2;GPI;HK2;...
Ferroptosis 1.85 1.53e-2 36/41 (87.8%) SLC7A11;FTH1;CYBB;...
TNF signaling pathway 1.82 1.43e-2 103/112 (91.96%) ATF4;CCL5;CXCL2;...
Legionellosis 1.74 3.67e-2 51/57 (89.47%) HSPA6;CD14;CXCL2;...
Complement and coagulation cascades -1.68 4.62e-2 76/85 (89.41%) CD46;C7;SERPINF2;...
Primary bile acid biosynthesis -1.75 2.37e-2 15/17 (88.24%) CYP27A1;SCP2;AKR1C4;...
Peroxisome -1.76 2.35e-2 72/82 (87.8%) SOD1;EPHX2;PAOX;...
Fatty acid degradation -1.79 1.95e-2 40/43 (93.02%) ADH6;ALDH3A2;ACAA1;...
Drug metabolism -1.83 1.42e-2 78/151 (51.66%) DPYS;MGST2;ALDH3A1;...
Oxidative phosphorylation -1.86 1.54e-2 93/133 (69.92%) ATP5PO;ATP5F1D;NDUFV2;...
Metabolism of xenobiotics by cytochrome P450 -1.87 1.71e-2 49/77 (63.64%) MGST2;ALDH3A1;GSTM2;...
Fatty acid elongation -2.00 5.70e-3 19/27 (70.37%) HACD1;TECR;ACOT7;...
Retinol metabolism -2.11 4.27e-3 41/68 (60.29%) CYP2C18;UGT2B4;UGT2A3;...
Biosynthesis of unsaturated fatty acids -2.35 0.00e+0 21/27 (77.78%) HACD1;ACAA1;TECR;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H