Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5OHYE)

• Drug Name: Bacitracin Drug Info
• Synonyms: Altracin; Baciguent; Baciquent; Citracin; Fortracin; Bacitracin A; Bacitracin A1; Bacitracin A2a; Neosporin (TN); Solu-Tracin 50; Partyl-, (10.4)-lactam; L-Asparagine, N-[[(4R)-2-[(1S,2S)-1-amino-2-methylbutyl]-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-.alpha.-glutamyl-L-isoleucyl-L-lysyl-D-ornithyl-L-isoleucyl-D-phenylalanyl-L-histidyl-D-.alpha.-as; 11702_FLUKA; 11702_SIGMA
• Therapeutic Class: Antibiotics
• Cross-matching ID:
  PubChem CID: 10909430
  ChEBI ID: CHEMBL1200558
  CAS Number: CAS 1405-87-4
  TTD Drug ID: D0M1IO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Complement and coagulation cascades	2.29	0.00e+0	76/85 (89.41%)	CFI;CFD;CLU;...
Staphylococcus aureus infection	2.23	0.00e+0	72/95 (75.79%)	KRT13;DEFB1;CFI;...
DNA replication	1.99	7.29e-3	34/36 (94.44%)	RPA3;PRIM1;MCM2;...
Neutrophil extracellular trap formation	1.90	1.37e-2	101/189 (53.44%)	PRKCA;ELANE;C3;...
PPAR signaling pathway	1.85	1.53e-2	66/74 (89.19%)	FABP5;SORBS1;APOA2;...
Fatty acid degradation	1.84	1.28e-2	40/43 (93.02%)	ACAT2;ALDH9A1;ECHS1;...
Systemic lupus erythematosus	1.78	2.03e-2	45/135 (33.33%)	HLA-DQA1;ELANE;C3;...
Bacterial invasion of epithelial cells	1.76	2.73e-2	59/77 (76.62%)	CAV1;CDC42;CRK;...
Biosynthesis of unsaturated fatty acids	1.72	3.89e-2	21/27 (77.78%)	HACD1;TECR;SCD;...
Ubiquinone and other terpenoid-quinone biosynthesis	1.69	4.48e-2	9/11 (81.82%)	NQO1;HPD;GGCX;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H	Hide ▲

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	10uM	6H, 24H	Hide ▲