Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5PVQE)

Drug Name
Paroxetine Drug Info
Synonyms Seroxat (TN)
Therapeutic ClassAntidepressants
Cross-matching ID
PubChem CID
43815
ChEBI ID
CHEMBL490
CAS Number
CAS 61869-08-7
TTD Drug ID
D06GDY
VARIDT Drug ID
DR00403
INTEDE Drug ID
DR1245
ACDINA Drug ID
D00511

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.51 0.00e+0 19/20 (95%) MSMO1;DHCR24;SQLE;...
PPAR signaling pathway 2.18 0.00e+0 66/74 (89.19%) SCD;HMGCS1;ACSL1;...
Synthesis and degradation of ketone bodies 2.09 2.85e-3 9/10 (90%) HMGCS1;ACAT2;OXCT1
AMPK signaling pathway 2.05 2.14e-3 106/120 (88.33%) SCD;FOXO3;IRS2;...
Terpenoid backbone biosynthesis 2.05 1.71e-3 18/22 (81.82%) HMGCS1;IDI1;FDPS;...
mTOR signaling pathway 2.03 1.42e-3 114/154 (74.03%) LPIN1;DDIT4;RRAGC;...
Adipocytokine signaling pathway 1.90 8.55e-3 64/69 (92.75%) IRS2;ACSL1;NFKBIA;...
Biosynthesis of unsaturated fatty acids 1.82 1.50e-2 21/27 (77.78%) SCD;FADS1;ELOVL5;...
Glyoxylate and dicarboxylate metabolism 1.80 2.18e-2 23/30 (76.67%) GLUL;ACAT2;SHMT1;...
Arginine biosynthesis 1.72 4.02e-2 17/22 (77.27%) GLUL;ASS1;GLUD1;...
Circadian rhythm 1.72 3.89e-2 26/31 (83.87%) PER1;PRKAA1;BHLHE40;...
Autophagy 1.69 4.91e-2 113/169 (66.86%) IRS2;DDIT4;RRAGC;...
Phagosome 1.68 4.73e-2 118/152 (77.63%) MPO;CD36;ATP6V1B1;...
Aldosterone-regulated sodium reabsorption 1.68 4.64e-2 34/37 (91.89%) SCNN1A;SGK1;INSR;...
Valine, leucine and isoleucine degradation 1.67 4.73e-2 42/48 (87.5%) HMGCS1;ACAT2;AOX1;...
Staphylococcus aureus infection 1.66 4.91e-2 72/95 (75.79%) CFD;DEFB1;CFB;...
Ferroptosis 1.66 4.78e-2 36/41 (87.8%) ACSL1;ACSL3;MAP1LC3B;...
Leukocyte transendothelial migration 1.66 4.51e-2 90/114 (78.95%) GNAI1;EZR;VCAM1;...
Collecting duct acid secretion 1.64 4.99e-2 22/27 (81.48%) ATP6V1B1;ATP6V1A;ATP6V1B2;...
Proteasome -1.84 4.23e-2 44/46 (95.65%) PSMD13;PSMA3;PSME2;...
DNA replication -1.96 4.83e-2 34/36 (94.44%) RNASEH2A;DNA2;POLD4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H