Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5Q1W4)

Drug Name
YM155 Drug Info
Synonyms Sepantronium
Cross-matching ID
PubChem CID
11178236
ChEBI ID
CHEMBL2105734
CAS Number
CAS 781661-94-7
TTD Drug ID
D06YWH
VARIDT Drug ID
DR00110

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Bladder cancer 2.06 0.00e+0 40/41 (97.56%) CXCL8;HBEGF;MYC;...
IL-17 signaling pathway 2.04 0.00e+0 84/94 (89.36%) NFKBIA;CXCL8;FOSL1;...
Arginine and proline metabolism 1.99 0.00e+0 39/50 (78%) AOC1;SAT1;ODC1;...
Fructose and mannose metabolism 1.89 9.22e-3 30/33 (90.91%) HK2;AKR1B10;PFKP;...
TNF signaling pathway 1.88 9.84e-3 103/112 (91.96%) NFKBIA;TNFAIP3;FOS;...
ErbB signaling pathway 1.88 8.20e-3 79/85 (92.94%) AREG;HBEGF;MYC;...
Circadian rhythm 1.87 7.03e-3 26/31 (83.87%) BHLHE40;CSNK1E;PER2;...
Central carbon metabolism in cancer 1.87 7.69e-3 67/70 (95.71%) MYC;EGFR;HK2;...
Colorectal cancer 1.86 6.83e-3 84/86 (97.67%) AREG;MYC;EGFR;...
Nitrogen metabolism 1.86 7.38e-3 16/17 (94.12%) CA2;GLUL;CA9;...
Cellular senescence 1.85 6.71e-3 139/156 (89.1%) CXCL8;MYC;CDKN1A;...
NF-kappa B signaling pathway 1.85 6.15e-3 90/104 (86.54%) NFKBIA;CXCL8;TNFAIP3;...
Glycolysis / Gluconeogenesis 1.85 5.68e-3 56/67 (83.58%) HK2;ENO2;PFKP;...
HIF-1 signaling pathway 1.84 6.15e-3 105/109 (96.33%) EGFR;HK2;CDKN1A;...
TGF-beta signaling pathway 1.82 8.20e-3 81/94 (86.17%) ID1;BMP2;MYC;...
C-type lectin receptor signaling pathway 1.80 8.45e-3 93/104 (89.42%) NFKBIA;EGR3;IRF1;...
MAPK signaling pathway 1.78 8.68e-3 272/294 (92.52%) DUSP5;AREG;MYC;...
Hippo signaling pathway 1.75 1.57e-2 120/186 (64.52%) ID1;AREG;BMP2;...
Thyroid cancer 1.75 1.49e-2 36/37 (97.3%) MYC;CDKN1A;GADD45A;...
Ribosome 1.75 1.41e-2 113/158 (71.52%) MRPS2;MRPL23;RPS4Y1;...
Pancreatic cancer 1.74 1.46e-2 75/76 (98.68%) EGFR;CDKN1A;VEGFA;...
Epithelial cell signaling in Helicobacter pylori infect... 1.73 1.51e-2 62/70 (88.57%) NFKBIA;CXCL8;HBEGF;...
p53 signaling pathway 1.73 1.44e-2 63/73 (86.3%) CDKN1A;SFN;GADD45A;...
Thiamine metabolism 1.71 2.05e-2 12/15 (80%) AK4;AK2;TPK1;...
Estrogen signaling pathway 1.70 2.36e-2 119/137 (86.86%) HBEGF;EGFR;FOS;...
T cell receptor signaling pathway 1.70 2.27e-2 93/104 (89.42%) NFKBIA;FOS;CSF2;...
Prostate cancer 1.69 2.46e-2 93/97 (95.88%) NFKBIA;EGFR;CDKN1A;...
Fluid shear stress and atherosclerosis 1.69 2.59e-2 123/139 (88.49%) NQO1;HMOX1;FOS;...
Osteoclast differentiation 1.66 3.56e-2 117/127 (92.13%) NFKBIA;FOSL1;FHL2;...
Human T-cell leukemia virus 1 infection 1.65 3.65e-2 197/219 (89.95%) NFKBIA;FOSL1;MYC;...
Glycosylphosphatidylinositol (GPI)-anchor biosynthesis -1.68 3.54e-2 20/26 (76.92%) PIGP;PIGV;PIGQ;...
Lysosome -1.69 3.56e-2 115/128 (89.84%) ATP6V0A4;ABCB9;ASAH1;...
Fatty acid biosynthesis -1.69 3.88e-2 16/18 (88.89%) HSD17B8;ACACB;ACSL5;...
Other glycan degradation -1.71 4.07e-2 13/18 (72.22%) HEXB;MAN2B2;ENGASE;...
Phosphatidylinositol signaling system -1.80 1.36e-2 82/97 (84.54%) PLCB1;INPP5B;DGKD;...
Terpenoid backbone biosynthesis -1.80 1.70e-2 18/22 (81.82%) MVD;HMGCS2;DHDDS;...
Various types of N-glycan biosynthesis -2.00 0.00e+0 26/39 (66.67%) ALG12;RPN2;MAN1A1;...
N-Glycan biosynthesis -2.02 0.00e+0 38/50 (76%) RPN2;MAN1A1;B4GALT2;...
Steroid biosynthesis -2.20 0.00e+0 19/20 (95%) FDFT1;DHCR7;MSMO1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 0.3uM 6H
SK-ES-1 CVCL_0627 Homo sapiens 0.12uM - 1.11uM 24H
TC-32 CVCL_7141 Homo sapiens 0.12uM - 1.11uM 24H
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Brain
Glioblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-251 MG CVCL_0021 Homo sapiens 10uM 24H
YH-13 CVCL_1800 Homo sapiens 0.12uM 24H
Glioma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
GI-1 CVCL_1230 Homo sapiens 10uM 24H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 2.22uM 24H
MDA-MB-468 CVCL_0419 Homo sapiens 0.12uM - 10uM 24H
Breast ductal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BT-474 CVCL_0179 Homo sapiens 0.12uM - 10uM 24H
T-47D CVCL_0553 Homo sapiens 0.12uM - 10uM 24H
ZR-75-1 CVCL_0588 Homo sapiens 0.12uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 2.22uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 0.3uM 6H
GP2d CVCL_1234 Homo sapiens 0.12uM - 1.11uM 24H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 0.3uM 6H
MDST8 CVCL_1400 Homo sapiens 0.3uM 6H
NCI-H508 CVCL_1561 Homo sapiens 0.3uM 6H
SNU-1040 CVCL_5001 Homo sapiens 0.3uM 6H
SNU-407 CVCL_5004 Homo sapiens 0.12uM - 10uM 24H
SNU-C4 CVCL_5008 Homo sapiens 0.3uM 6H
SNU-C5 CVCL_5009 Homo sapiens 0.3uM 6H
SW480 CVCL_0546 Homo sapiens 0.3uM 6H
SW620 CVCL_0547 Homo sapiens 0.3uM 6H
SW948 CVCL_0550 Homo sapiens 0.3uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 0.3uM 6H
HT115 CVCL_1294 Homo sapiens 0.3uM 6H
RKO CVCL_0504 Homo sapiens 0.3uM 6H
Embryonic stem cell
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WA09 (H9) Derived CVCL_9773 (WA09) Homo sapiens 0.12uM - 10uM 24H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 0.12uM - 10uM 6H, 24H
HEC-151 CVCL_2927 Homo sapiens 0.12uM - 1.11uM 24H
HEC-1-A CVCL_0293 Homo sapiens 0.12uM - 10uM 24H
HEC-251 CVCL_2928 Homo sapiens 0.12uM - 10uM 24H
HEC-265 CVCL_2929 Homo sapiens 0.12uM - 1.11uM 24H
SNG-M CVCL_1707 Homo sapiens 0.3uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 0.3uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
CJM CVCL_U797 Homo sapiens 0.12uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 2.22uM 24H
Renal cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RCC10RGB CVCL_1656 Homo sapiens 0.12uM - 10uM 24H
Rhabdoid tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
G-401 CVCL_0270 Homo sapiens 0.12uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHH-5 CVCL_1320 Homo sapiens 0.12uM - 10uM 24H
JHH-7 CVCL_1322 Homo sapiens 0.12uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
DV-90 CVCL_1184 Homo sapiens 0.3uM 6H
NCI-H1573 CVCL_1483 Homo sapiens 0.12uM - 10uM 24H
NCI-H838 CVCL_1594 Homo sapiens 0.12uM 24H
SK-LU-1 CVCL_0624 Homo sapiens 0.3uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 0.3uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 0.3uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BEN CVCL_1081 Homo sapiens 0.12uM - 10uM 24H
HCC15 CVCL_1253 Homo sapiens 0.3uM 6H
HCC1588 CVCL_1263 Homo sapiens 0.12uM - 10uM 24H
HCC95 CVCL_1276 Homo sapiens 0.12uM - 10uM 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 0.3uM 6H
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 0.3uM 6H
NCI-H2110 CVCL_1529 Homo sapiens 0.12uM - 1.11uM 24H
NCI-H2172 CVCL_1534 Homo sapiens 0.12uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1694 CVCL_1495 Homo sapiens 0.3uM 6H
NCI-H1836 CVCL_1502 Homo sapiens 0.3uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 0.3uM 6H
Muscle
Rhabdomyosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-204 CVCL_0134 Homo sapiens 0.12uM - 10uM 24H
Oral cavity
Oral squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BICR 6 CVCL_1086 Homo sapiens 0.12uM - 1.11uM 24H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 0.3uM 6H
OV7 CVCL_1623 Homo sapiens 0.3uM 6H
OVK18 CVCL_1629 Homo sapiens 0.12uM 24H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ES-2 CVCL_3509 Homo sapiens 0.12uM - 10uM 24H
OVTOKO CVCL_3114 Homo sapiens 0.12uM - 10uM 24H
RMG-I CVCL_1663 Homo sapiens 0.3uM 6H
Ovarian cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
OAW 28 CVCL_1611 Homo sapiens 0.12uM - 10uM 24H
OC 316 CVCL_1615 Homo sapiens 0.12uM 24H
Ovarian endometrioid carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TOV-112D CVCL_3612 Homo sapiens 0.12uM - 10uM 24H
Ovarian granulosa cell tumor
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV434 CVCL_2010 Homo sapiens 0.12uM - 10uM 24H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 0.3uM 6H
RMUG-S CVCL_1666 Homo sapiens 0.3uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 0.3uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 0.3uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 0.3uM 6H
PL-21 CVCL_2161 Homo sapiens 0.3uM 6H
SKM-1 CVCL_0010 Homo sapiens 0.3uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 2.22uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 0.3uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
22Rv1 CVCL_1045 Homo sapiens 0.12uM - 10uM 24H
LNCaP clone FGC CVCL_1379 Homo sapiens 0.12uM - 1.11uM 24H
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 0.3uM - 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
IGR-37 CVCL_1303 Homo sapiens 0.12uM 24H
Mel-HO CVCL_1402 Homo sapiens 0.12uM - 10uM 24H
SH-4 CVCL_1692 Homo sapiens 0.12uM 24H
SK-MEL-1 CVCL_0523 Homo sapiens 0.3uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 0.3uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 0.12uM - 1.11uM 6H, 24H
MKN45 CVCL_0434 Homo sapiens 0.12uM - 10uM 24H
Gastric carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
IM95 CVCL_1305 Homo sapiens 0.12uM - 1.11uM 24H
Urinary bladder
Bladder carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
BC-3C CVCL_1079 Homo sapiens 0.12uM - 10uM 24H
Bladder transitional cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CAL-29 CVCL_1109 Homo sapiens 0.12uM 24H