Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5QF9V)

Drug Name
Tamsulosin Drug Info
Synonyms
Flomax; Flowmax; Harnal; Tamsolusin; Tamsulon; Tamsulosina; Tamsulosine; Tamsulosinum; Flomax (TN); Flomaxtra (TN); Tamsulon (TN); Tamsulosin (INN); Tamsulosin [INN:BAN]; Tamsulosina [INN-Spanish]; Tamsulosine [INN-French]; Tamsulosinum [INN-Latin]; Urimax (TN); (R)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide; 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide; 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide; 5-[(2R)-2-{[2-(2-ethoxyphenoxy)ethyl]amino}propyl]-2-methoxybenzenesulfonamide; 5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxy-benzenesulfonamide; 5-{(2R)-2-[(2-{[2-(ethyloxy)phenyl]oxy}ethyl)amino]propyl}-2-(methyloxy)benzenesulfonamide
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
129211
ChEBI ID
CHEMBL836
CAS Number
CAS 106133-20-4
TTD Drug ID
D05MBZ
INTEDE Drug ID
DR1530
ACDINA Drug ID
D00651

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.33 0.00e+0 34/36 (94.44%) MCM2;RPA3;PCNA;...
Complement and coagulation cascades 2.06 0.00e+0 76/85 (89.41%) CFH;SERPINA1;CD59;...
Mismatch repair 2.02 0.00e+0 22/23 (95.65%) RPA3;MSH2;PCNA;...
Pertussis 1.95 0.00e+0 64/76 (84.21%) CXCL8;MAPK13;CALML3;...
Legionellosis 1.93 0.00e+0 51/57 (89.47%) CXCL8;HSPA8;HSPA1A;...
Staphylococcus aureus infection 1.90 3.05e-3 72/95 (75.79%) CFH;DEFB1;KRT19;...
Drug metabolism 1.86 3.92e-3 78/151 (51.66%) TK1;RRM2;GSTO1;...
Cell cycle 1.85 4.57e-3 110/124 (88.71%) SFN;E2F2;CCNB2;...
Glutathione metabolism 1.84 4.06e-3 43/57 (75.44%) GPX2;RRM2;LAP3;...
Pyrimidine metabolism 1.79 1.01e-2 40/56 (71.43%) TK1;RRM2;TYMS;...
Parkinson disease 1.77 1.33e-2 176/249 (70.68%) CALML3;GNAI1;TUBB;...
Amyotrophic lateral sclerosis 1.76 1.45e-2 267/364 (73.35%) GPX2;MAPK13;TUBB;...
Oxidative phosphorylation 1.74 1.62e-2 93/133 (69.92%) PPA1;ATP5PD;ATP6V0E2;...
Spliceosome 1.73 1.70e-2 101/150 (67.33%) HSPA8;HSPA1A;HSPA6;...
Bladder cancer 1.67 3.29e-2 40/41 (97.56%) E2F2;CXCL8;MMP1;...
Phagosome 1.67 3.14e-2 118/152 (77.63%) TUBB;CYBA;TUBB2A;...
Glycolysis / Gluconeogenesis 1.67 3.01e-2 56/67 (83.58%) PGAM1;PGK1;DLD;...
Prion disease 1.66 3.45e-2 209/273 (76.56%) HSPA8;MAPK13;TUBB;...
Oocyte meiosis 1.66 3.37e-2 90/129 (69.77%) MAPK13;CALML3;CCNB2;...
Metabolism of xenobiotics by cytochrome P450 1.65 3.20e-2 49/77 (63.64%) AKR1C1;CBR3;GSTO1;...
Nucleotide excision repair 1.65 3.22e-2 40/47 (85.11%) RPA3;PCNA;RPA2;...
Ferroptosis 1.63 3.82e-2 36/41 (87.8%) TF;FTH1;SAT1;...
Fat digestion and absorption 1.61 4.69e-2 35/43 (81.4%) ACAT2;FABP1;APOA1;...
Phosphatidylinositol signaling system -1.80 3.32e-2 82/97 (84.54%) SACM1L;PLCB4;IP6K1;...
Inositol phosphate metabolism -1.85 2.58e-2 66/73 (90.41%) PIK3C2A;INPP5J;PI4KB;...
Primary immunodeficiency -2.04 1.11e-2 33/38 (86.84%) CD8A;ADA;TAP2;...
Notch signaling pathway -2.17 0.00e+0 49/59 (83.05%) DTX2;NOTCH3;MFNG;...
×

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 8uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 2.22uM 24H