Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5QWEL)

Drug Name
Guanabenz Drug Info
Synonyms
GBZ; Guanabenzo; Guanabenzum; Wytensin; Guanabenz acetate; Guanabenz monoacetate; Wy 8678; Wy 8678 base; BR-750; Guanabenz [USAN:INN]; Guanabenz(USAN); Guanabenzo [INN-Spanish]; Guanabenzum [INN-Latin]; Wy-8678; Wytensin (TN); Guanabenz (USAN/INN); [(2,6-Dichlorobenzylidene)amino]guanidine; N-((2,6-Dichlorobenzylidene)amino)guanidine; Guanidine, ((2,6-dichlorobenzylidene)amino)-(8CI); N-(2,6-Dichlorobenzylidene)-N'-amidinohydrazine; ((2,6-Dichlorobenzylidene)amino)guanidine; 2,6-Dichlorobenzylideneaminoguanidine;2-((2,6-Dichlorophenyl)methylene)-hydrazinecarboximidamide; 2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine
Therapeutic ClassSympatholytics
Cross-matching ID
PubChem CID
5702063
ChEBI ID
CHEMBL420
CAS Number
CAS 60329-03-5
TTD Drug ID
D0L4HY
VARIDT Drug ID
DR01410
INTEDE Drug ID
DR0794

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.37 0.00e+0 34/36 (94.44%) PCNA;RFC4;MCM7;...
Mismatch repair 2.06 0.00e+0 22/23 (95.65%) PCNA;RFC4;LIG1;...
Mineral absorption 1.97 3.74e-3 48/60 (80%) MT1F;MT1X;MT1E;...
Fanconi anemia pathway 1.84 8.42e-3 36/54 (66.67%) FANCI;RPA3;BRCA1;...
Steroid biosynthesis 1.80 1.80e-2 19/20 (95%) DHCR24;DHCR7;TM7SF2;...
GABAergic synapse 1.79 1.50e-2 76/89 (85.39%) GNAI1;ABAT;SLC38A1;...
Progesterone-mediated oocyte maturation 1.78 1.76e-2 75/100 (75%) GNAI1;CCNB1;MAPK13;...
Type II diabetes mellitus 1.76 1.96e-2 42/46 (91.3%) ADIPOQ;PIK3CD;PKM;...
Regulation of lipolysis in adipocytes 1.75 2.49e-2 52/55 (94.55%) GNAI1;PTGER3;NPY1R;...
Pyrimidine metabolism 1.72 3.25e-2 40/56 (71.43%) RRM2;TYMP;DTYMK;...
Valine, leucine and isoleucine degradation 1.71 3.16e-2 42/48 (87.5%) ABAT;ALDH1B1;HMGCS1;...
Cell cycle 1.69 3.55e-2 110/124 (88.71%) CCNB1;PCNA;CCND2;...
Morphine addiction 1.68 4.06e-2 80/91 (87.91%) GNAI1;ADCY1;PDE4A;...
Base excision repair 1.67 4.01e-2 29/33 (87.88%) PCNA;LIG1;FEN1;...
Fructose and mannose metabolism 1.66 3.82e-2 30/33 (90.91%) PFKFB3;SORD;ALDOA;...
Homologous recombination 1.66 4.07e-2 35/41 (85.37%) RPA3;BRCA1;POLD3;...
Biosynthesis of unsaturated fatty acids 1.64 4.29e-2 21/27 (77.78%) SCD;FADS1;FADS2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 15uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H