Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5SYZP)

Drug Name
Disopyramide Drug Info
Synonyms
Dicorantil; Disopiramida; Disopyramidum; Isorythm; Lispine; Ritmodan; Rythmodan; Disopyramide Free Base; Rythmodan P; D 7644; H 3292; SC 7031; Searle 703; Disopiramida [INN-Spanish]; Disopyramidum [INN-Latin]; Norpace (TN); Rythmodan (TN); Rythmodan P (TN); Rythmodan-La; SC-7031; Xi-Disopyramide; Disopyramide (JP15/USAN/INN); Disopyramide [USAN:BAN:INN:JAN]; Alpha-Diisopropylaminoethyl-alpha-phenylpyridine-2-acetamide; Gamma-Diisopropylamino-alpha-phenyl-alpha-(2-pyridyl)butyramide; Alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide; Alpha-[2-[Bis(1-methylethyl)amino]ethyl]-alpha-phenyl-2-pyridine acetamide; 4-(diisopropylamino)-2-phenyl-2-pyridin-2-ylbutanamide; 4-[di(propan-2-yl)amino]-2-phenyl-2-pyridin-2-ylbutanamide
Therapeutic ClassAntiarrhythmic Agents
Cross-matching ID
PubChem CID
3114
ChEBI ID
CHEMBL517
CAS Number
CAS 3737-09-5
TTD Drug ID
D0M4YC
VARIDT Drug ID
DR00644
INTEDE Drug ID
DR0518
ACDINA Drug ID
D00205

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Oxidative phosphorylation 2.50 0.00e+0 93/133 (69.92%) NDUFB5;COX17;COX6B1;...
Proteasome 2.31 0.00e+0 44/46 (95.65%) PSMD8;PSMC3;PSMA3;...
Parkinson disease 2.28 0.00e+0 176/249 (70.68%) CYCS;PSMD8;NDUFB5;...
Prion disease 2.17 0.00e+0 209/273 (76.56%) CYCS;PSMD8;NDUFB5;...
Huntington disease 2.13 0.00e+0 233/306 (76.14%) CYCS;GPX3;PSMD8;...
Pyruvate metabolism 1.87 6.03e-3 41/47 (87.23%) ADH5;ADH1B;PCK1;...
Diabetic cardiomyopathy 1.84 7.75e-3 162/203 (79.8%) GAPDH;TGFB1;NDUFB5;...
Pyrimidine metabolism 1.82 1.13e-2 40/56 (71.43%) UPP1;NME1;DCK;...
Thermogenesis 1.82 1.11e-2 173/232 (74.57%) NDUFB5;COX17;COX6B1;...
Non-alcoholic fatty liver disease 1.81 9.95e-3 126/155 (81.29%) CYCS;TGFB1;NDUFB5;...
Alzheimer disease 1.81 9.05e-3 279/369 (75.61%) CYCS;GAPDH;LPL;...
Riboflavin metabolism 1.75 2.49e-2 7/8 (87.5%) ACP5;RFK;BLVRB;...
RNA polymerase 1.73 2.50e-2 23/31 (74.19%) POLR2I;POLR3K;POLR2F;...
Ribosome 1.73 2.39e-2 113/158 (71.52%) MRPL15;MRPL22;MRPS12;...
Amyotrophic lateral sclerosis 1.71 2.47e-2 267/364 (73.35%) CYCS;GPX3;PSMD8;...
Tyrosine metabolism 1.68 3.84e-2 30/36 (83.33%) ADH5;ADH1B;GOT1;...
Malaria 1.67 3.94e-2 44/50 (88%) SDC1;TLR4;THBS1;...
Ribosome biogenesis in eukaryotes 1.66 3.82e-2 52/108 (48.15%) NVL;RPP30;RPP40;...
Glycolysis / Gluconeogenesis 1.64 4.48e-2 56/67 (83.58%) ADH5;GAPDH;ADH1B;...
Cortisol synthesis and secretion -1.89 4.38e-2 58/65 (89.23%) CACNA1D;ADCY2;ITPR1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 3H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.04uM - 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H