General Information of Drug (ID: DM5T6US)

Drug Name
Estrone Drug Info
Synonyms
Aquacrine; Crinovaryl; Cristallovar; Crystogen; Destrone; Disynformon; Endofolliculina; Esterone; Estrin; Estrol; Estron; Estrona; Estronum; Estrovarin; Estrugenone; Estrusol; Femidyn; Fermidyn; Folikrin; Folipex; Folisan; Follestrine; Follestrol; Folliculin; Folliculine; Follicunodis; Glandubolin; Hiestrone; Hormestrin; Hormofollin; Hormovarine; Kestrone; Ketodestrin; Ketohydroxyestrin; Ketohydroxyoestrin; Ketophydroxyestrin; Kolpon; Menagen; Menformon; Mestronaq; OESTRONE; Oestrin; Oestroform; Oestronum; Oestroperos; Ovifollin; Perlatan; Solliculin; Theelin; Thelestrin; Thelykinin; Thynestron; Tokokin; Unden; Unigen; Wehgen; Wynestron; Estrogenic Substance; Estrona [Spanish]; Femestrone injection; Follicular hormone; Folliculine benzoate; Hauck Brand of Estrone; Hyrex Brand of Estrone; Menformon A; Oestrone [Steroidal oestrogens]; Penncap M; Vortech Brand of Estrone; WynestronPencap M; CMC_13458; E 9750; E0026; E(sub 1); Estrona [INN-Spanish]; Estrone (E1); Estrone (TN); Estrone [USAN:INN]; Estrone-A; Estronum [INN-Latin]; Femestrone inj.; Ketohydroxy-Estratriene; NATURAL ESTROGENIC SUBSTANCE-ESTRONE; Oestrone, Estrone; Ovex (tablets); Unden (pharmaceutical); Unden (pharmaceutical) (VAN); Estrone (JAN/USP/INN); Estrone, (8 alpha)-Isomer; Estrone, (9 beta)-Isomer; Estrone, (+-)-Isomer; [2,4,6,7-3H]-E1; Delta-1,3,5-Estratrien-3beta-ol-17-one; Delta-1,3,5-Oestratrien-3beta-ol-17-one; Delta-1,3,5-estratrien-3-beta-ol-17-one; Delta-1,3,5-oestratrien-3-beta-ol-17-one; (13S)-3-hydroxy-13-methyl-7,8,9,11,12,13,15,16-octahydro-6H-cyclopenta[a]phenanthren-17(14H)-one; (8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one; 1,3,5(10)-Estratrien-3-ol-17-one; 1,3,5(10)-Oestratrien-3-ol-17-one; 3-Hydroxy-1,3,5(10)-estratrien-17-one; 3-Hydroxy-17-keto-estra-1,3,5-triene; 3-Hydroxy-17-keto-oestra-1,3,5-triene; 3-Hydroxy-oestra-1,3,5(10)-trien-17-one; 3-Hydroxyestra-1,3,5(10)-trien-17-one; 3-Hydroxyestra-1,3,5(10)-triene-17-one; 3-hydroxy-estra-1,3,5(10)-trien-17-one
Therapeutic ClassAntimenopausal Agents
Cross-matching ID
PubChem CID
5870
ChEBI ID
CHEMBL1405
CAS Number
CAS 53-16-7
TTD Drug ID
D00ZFP
VARIDT Drug ID
DR00494
INTEDE Drug ID
DR0648

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.69 0.00e+0 34/36 (94.44%) PRIM1;MCM4;POLE2;...
Ribosome biogenesis in eukaryotes 2.31 0.00e+0 52/108 (48.15%) NOP56;RPP40;NXT1;...
Cell cycle 2.23 0.00e+0 110/124 (88.71%) CDC20;CHEK1;MCM4;...
mRNA surveillance pathway 2.14 0.00e+0 71/98 (72.45%) NCBP1;NXT1;EIF4A3;...
Mismatch repair 2.13 0.00e+0 22/23 (95.65%) EXO1;RPA3;RFC4;...
RNA transport 1.98 0.00e+0 128/186 (68.82%) NDC1;RPP40;SEH1L;...
Spliceosome 1.93 7.39e-4 101/150 (67.33%) SRSF7;PRPF4;NCBP1;...
Purine metabolism 1.92 1.29e-3 102/129 (79.07%) ENPP1;GUCY1A1;PNP;...
Homologous recombination 1.88 1.15e-3 35/41 (85.37%) RAD54B;BARD1;RAD51;...
One carbon pool by folate 1.83 3.10e-3 15/20 (75%) MTHFD1;GART;ATIC;...
Nucleotide excision repair 1.81 5.17e-3 40/47 (85.11%) POLE2;POLE3;RPA3;...
RNA polymerase 1.79 5.61e-3 23/31 (74.19%) POLR3K;POLR2D;POLR3G;...
Oocyte meiosis 1.79 5.17e-3 90/129 (69.77%) CDC20;MAD2L1;AURKA;...
Pyrimidine metabolism 1.77 8.13e-3 40/56 (71.43%) ENPP1;PNP;RRM2;...
Proteasome 1.77 7.59e-3 44/46 (95.65%) PSMB10;PSMC4;PSMD1;...
Base excision repair 1.67 1.97e-2 29/33 (87.88%) POLE2;POLE3;NEIL3;...
Fanconi anemia pathway 1.65 2.37e-2 36/54 (66.67%) RAD51;RPA3;RPA2;...
Progesterone-mediated oocyte maturation 1.59 3.79e-2 75/100 (75%) MAD2L1;AURKA;PLK1;...
Cytosolic DNA-sensing pathway 1.55 4.90e-2 52/63 (82.54%) CXCL10;POLR3K;POLR3G;...
VEGF signaling pathway -1.62 4.91e-2 50/59 (84.75%) MAPK11;MAP2K1;PIK3CA;...
Tryptophan metabolism -1.63 4.63e-2 35/42 (83.33%) CYP1A1;EHHADH;ALDH8A1;...
Autoimmune thyroid disease -1.64 4.57e-2 46/53 (86.79%) HLA-A;HLA-E;HLA-DOB;...
Ether lipid metabolism -1.64 4.51e-2 32/49 (65.31%) PAFAH2;AGPS;PLD1;...
Human cytomegalovirus infection -1.65 4.30e-2 201/225 (89.33%) EGFR;GNAO1;MAPK11;...
Proteoglycans in cancer -1.66 4.37e-2 172/205 (83.9%) IHH;EGFR;MAPK11;...
Graft-versus-host disease -1.66 4.58e-2 32/42 (76.19%) IL6;HLA-A;HLA-E;...
Fluid shear stress and atherosclerosis -1.66 4.83e-2 123/139 (88.49%) KEAP1;BMPR2;IL1A;...
Allograft rejection -1.67 4.68e-2 32/38 (84.21%) HLA-A;HLA-E;HLA-DOB;...
Focal adhesion -1.67 4.95e-2 180/201 (89.55%) RAC1;ITGA8;DOCK1;...
Primary bile acid biosynthesis -1.68 4.51e-2 15/17 (88.24%) SLC27A5;HSD17B4;CYP39A1;...
Glioma -1.71 3.91e-2 67/75 (89.33%) PLCG2;SHC3;PRKCA;...
Bacterial invasion of epithelial cells -1.72 3.87e-2 59/77 (76.62%) PIK3CA;CLTC;ELMO2;...
Non-small cell lung cancer -1.72 4.05e-2 70/72 (97.22%) STAT5A;PLCG2;PRKCA;...
Sulfur metabolism -1.74 3.76e-2 9/10 (90%) ETHE1;SUOX;SELENBP1;...
Protein digestion and absorption -1.77 3.01e-2 78/103 (75.73%) COL11A2;COL9A2;SLC36A1;...
Hepatocellular carcinoma -1.80 1.80e-2 135/168 (80.36%) PTEN;RPS6KB1;KEAP1;...
Other glycan degradation -1.81 1.84e-2 13/18 (72.22%) MAN2C1;HEXB;MAN2B2;...
Endocrine and other factor-regulated calcium reabsorpti... -1.81 2.07e-2 49/53 (92.45%) PTH1R;FXYD2;VDR;...
Gastric cancer -1.82 1.93e-2 122/149 (81.88%) SHC3;CTNNB1;FGFR2;...
Axon guidance -1.85 1.25e-2 151/182 (82.97%) EPHB3;PLXNA3;EFNA5;...
Aldosterone-regulated sodium reabsorption -1.92 9.02e-3 34/37 (91.89%) PRKCA;NEDD4L;MAPK3;...
Lysosome -1.94 1.13e-2 115/128 (89.84%) SGSH;CLN3;IDUA;...
Mitophagy -1.94 1.50e-2 56/68 (82.35%) CSNK2A1;CALCOCO2;RELA;...
Histidine metabolism -1.96 7.52e-3 16/22 (72.73%) ALDH3A2;ALDH9A1;ALDH2;...
Basal cell carcinoma -2.05 0.00e+0 41/63 (65.08%) CTNNB1;LEF1;TCF7;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 0.12uM - 10uM 6H, 24H, 48H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 6H, 24H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 0.04uM - 10uM 6H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12.5uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 6H, 24H, 48H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 0.04uM - 10uM 6H, 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 6H, 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H