Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5TMYC)

Drug Name
iOWH032 Drug Info
Synonyms IOWH-032; CFTR inhibitors (diarrhea), BioFocus
Cross-matching ID
PubChem CID
135565181
CAS Number
CAS 1191252-49-9
TTD Drug ID
D0N4PW
VARIDT Drug ID
DR01042

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.07 0.00e+0 34/36 (94.44%) PCNA;MCM2;MCM6;...
Non-homologous end-joining 2.07 0.00e+0 11/13 (84.62%) DNTT;FEN1;PRKDC;...
Fanconi anemia pathway 1.90 2.61e-2 36/54 (66.67%) RAD51;FANCI;MLH1;...
Mismatch repair 1.86 1.96e-2 22/23 (95.65%) PCNA;MLH1;RFC3;...
PPAR signaling pathway 1.83 1.57e-2 66/74 (89.19%) FABP4;PLIN1;ADIPOQ;...
One carbon pool by folate 1.79 1.74e-2 15/20 (75%) TYMS;MTHFD1;ATIC;...
Steroid biosynthesis 1.79 1.49e-2 19/20 (95%) HSD17B7;DHCR24;DHCR7;...
Citrate cycle (TCA cycle) 1.79 1.31e-2 30/30 (100%) MDH1;IDH3B;IDH1;...
Ubiquinone and other terpenoid-quinone biosynthesis 1.76 1.55e-2 9/11 (81.82%) HPD;NQO1;COQ7;...
Spliceosome 1.75 1.48e-2 101/150 (67.33%) HSPA8;SNRPB;PUF60;...
Ribosome biogenesis in eukaryotes 1.74 1.82e-2 52/108 (48.15%) NOP56;NXT1;RPP40;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H