Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5URA2)

• Drug Name: Chlorpheniramine Drug Info
• Synonyms: Allergican; Allergisan; Antagonate; Chloropheniramine; Chlorophenylpyridamin; Chlorophenylpyridamine; Chloropiril; Chloroprophenpyridamine; Chlorphenamine; Chlorphenaminum; Chlorpheniraminum; Chlorprophenpyridamine; Clofeniramina; Clorfenamina; Clorfeniramina; Cloropiril; Haynon; Hayon; Histadur; ISOCLOR; Kloromin; Phenetron; PiriIton; Piriton; Polaronil; Telachlor; Teldrin; Chlorphenamine [INN]; Clorfeniramina [Italian]; Pediacare Allergy Formula; [3H]Chlorpheniramine; Aller-Chlor; Chlo-amine; Chlor-Pro; Chlor-Trimeton Repetabs; Chlor-trimeton; Chlorphenamine (INN); Chlorphenaminum [INN-Latin]; Clofeniramina (TN); Clorfenamina [INN-Spanish]; Comakin (TN); Gen-Allerate; Novo-Pheniram; Piriton (TN); Chlor-Trimeton (TN); Chlor-Tripolon (TN); CHLORPHENIRAMINE (SEE ALSO: CHLORPHENIRAMINE MALEATE (CAS113-92-8)); Gamma-(4-Chlorophenyl)-gamma-(2-pyridyl)propyldimethylamine; Gamma-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine; 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpropylamine; 1-(p-Chlorophenyl)-1-(2-pyridyl)-3-dimethylaminopropane; 2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine; 3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine; 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine; 3-(p-Chlorophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine; 4-Chloropheniramine
• Therapeutic Class: Antiallergic Agents
• Cross-matching ID:
  PubChem CID: 2725
  ChEBI ID: CHEMBL505
  CAS Number: CAS 113-92-8
  TTD Drug ID: D0B7NG
  VARIDT Drug ID: DR00595
  INTEDE Drug ID: DR0304
  ACDINA Drug ID: D00123

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
DNA replication	2.21	0.00e+0	34/36 (94.44%)	RFC4;RPA3;MCM5;...
Steroid biosynthesis	1.82	4.01e-2	19/20 (95%)	TM7SF2;FDFT1;SOAT1;...
Coronavirus disease	-1.65	4.83e-2	215/232 (92.67%)	MBL2;F13B;IFNAR2;...
Viral myocarditis	-1.67	4.31e-2	53/60 (88.33%)	HLA-DOA;HLA-DPA1;HLA-G;...
Neutrophil extracellular trap formation	-1.69	3.47e-2	101/189 (53.44%)	RAC1;HDAC5;VDAC2;...
Endocytosis	-1.69	3.62e-2	198/252 (78.57%)	DAB2;TSG101;SPG21;...
Complement and coagulation cascades	-1.70	3.27e-2	76/85 (89.41%)	CFB;CFHR2;C9;...
Lipid and atherosclerosis	-1.71	3.35e-2	190/215 (88.37%)	NFKB1;CASP8;CYP2C9;...
Allograft rejection	-1.71	3.53e-2	32/38 (84.21%)	HLA-DOA;HLA-DPA1;HLA-G;...
Leukocyte transendothelial migration	-1.71	3.82e-2	90/114 (78.95%)	MSN;CLDN3;MAPK11;...
Salmonella infection	-1.74	2.98e-2	198/249 (79.52%)	MAPK8;MAPK10;BCL2;...
Tuberculosis	-1.74	3.27e-2	159/180 (88.33%)	HLA-DOA;HLA-DPA1;FCGR2B;...
Bacterial invasion of epithelial cells	-1.77	2.55e-2	59/77 (76.62%)	ARPC1A;ARPC1B;ARPC5;...
Phagosome	-1.77	2.59e-2	118/152 (77.63%)	RAC1;HLA-DRA;CTSL;...
Pertussis	-1.81	2.34e-2	64/76 (84.21%)	TLR4;ITGB2;PYCARD;...
Amoebiasis	-1.85	1.64e-2	99/102 (97.06%)	SERPINB3;C9;RELA;...
Legionellosis	-1.92	2.18e-3	51/57 (89.47%)	BNIP3;NFKB1;CASP8;...
Antigen processing and presentation	-1.95	2.73e-3	60/78 (76.92%)	HLA-DOA;HLA-DPA1;HLA-G;...
IL-17 signaling pathway	-2.00	0.00e+0	84/94 (89.36%)	FADD;MAP3K7;MMP3;...
Leishmaniasis	-2.15	0.00e+0	67/77 (87.01%)	TLR2;HLA-DOA;HLA-DPA1;...
Staphylococcus aureus infection	-2.20	0.00e+0	72/95 (75.79%)	CFB;KRT18;CAMP;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	4uM	6H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.08uM - 40uM	3H, 6H, 24H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	12uM	72H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 20uM	6H, 24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H, 24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.01uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 10uM	24H	Show ▼