Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5VJAF)

Drug Name
SB-271046 Drug Info
Synonyms
209481-20-9; SB-271046; SB271046; Sb 271046; 5-chloro-N-(4-methoxy-3-(piperazin-1-yl)phenyl)-3-methylbenzo[b]thiophene-2-sulfonamide; UNII-L3SK5KX24S; L3SK5KX24S; CHEMBL431298; SB-271,046; C20H22ClN3O3S2; 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide; 5-chloro-N-(4-methoxy-3-piperazin-1-ylphenyl)-3-methyl-1-benzothiophene-2-sulfonamide; 5-Chloro-N-(4-methoxy-3-(1-piperazinyl)phenyl)-3-methylbenzo(b)thiophene-2-sulfonamide; AC1NSM3X; GTPL276; SCHEMBL194700; SB271046 HCl; BDBM28583; SB
Cross-matching ID
PubChem CID
5312149
ChEBI ID
CHEMBL431298
CAS Number
CAS 209481-20-9
TTD Drug ID
D07LRJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.10 0.00e+0 34/36 (94.44%) PCNA;MCM6;RFC3;...
Fructose and mannose metabolism 1.87 4.69e-2 30/33 (90.91%) PMM2;PFKL;HK2;...
Mismatch repair 1.87 3.13e-2 22/23 (95.65%) PCNA;RFC3;RFC2;...
Pentose phosphate pathway 1.87 2.35e-2 25/30 (83.33%) PGD;GPI;PFKL;...
Starch and sucrose metabolism 1.82 3.75e-2 25/36 (69.44%) GPI;PYGB;HK2;...
Base excision repair 1.75 4.69e-2 29/33 (87.88%) PCNA;FEN1;POLE3;...
Glutathione metabolism 1.74 4.62e-2 43/57 (75.44%) ODC1;PGD;GPX4;...
Glycolysis / Gluconeogenesis 1.74 4.17e-2 56/67 (83.58%) GPI;PKM;ALDH2;...
Steroid biosynthesis 1.71 4.40e-2 19/20 (95%) NSDHL;DHCR24;TM7SF2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.04uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.04uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H