Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5VWOB)

• Drug Name: Methylscopolamine Drug Info
• Synonyms: Methscopolamine; methscopolamine; N-Methylscopolamine; N-methyl scopolamine; UNII-VDR09VTQ8U; VDR09VTQ8U; 13265-10-6; CHEMBL376897; (1r,2r,4s,5s)-7-{[(2s)-3-hydroxy-2-phenylpropanoyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[33102,4]nonane; Metylskopolamin; 56552-70-6; 3-Oxa-9-azoniatricyclo[33102,4]nonane, 7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9,9-dimethyl-, (1a,2b,4b,5a,7b); HSDB 5420; [3H]N-methylscopolamine; [3H]N-methyl scopolamine; [3H]NMS; Methyl scopolamine; 3C0
• Therapeutic Class: Anticholinergic Agents
• Cross-matching ID:
  PubChem CID: 71183
  ChEBI ID: CHEMBL135361
  CAS Number: CAS 13265-10-6
  TTD Drug ID: D0M6VK

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Thyroid hormone synthesis	-1.65	4.37e-2	66/75 (88%)	ADCY8;ALB;ADCY2;...
Histidine metabolism	-1.66	3.97e-2	16/22 (72.73%)	HAL;CNDP2;HDC;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.70	2.82e-2	62/70 (88.57%)	CXCR2;EGFR;ATP6V1C1;...
NF-kappa B signaling pathway	-1.73	2.09e-2	90/104 (86.54%)	EDA;BTK;LCK;...
Insulin secretion	-1.76	1.64e-2	75/86 (87.21%)	ADCY8;KCNMB3;CCKAR;...
Cytokine-cytokine receptor interaction	-1.78	1.36e-2	246/295 (83.39%)	IL9;ACKR3;CSF1;...
Renin-angiotensin system	-1.78	1.28e-2	20/23 (86.96%)	CTSG;CTSA;ATP6AP2;...
Bile secretion	-1.79	1.28e-2	68/90 (75.56%)	ADCY8;UGT2B15;ADCY2;...
Pertussis	-1.81	1.19e-2	64/76 (84.21%)	NOS2;IRF3;LY96;...
Systemic lupus erythematosus	-1.82	1.09e-2	45/135 (33.33%)	FCGR2A;HLA-DRA;C1S;...
Legionellosis	-1.83	9.62e-3	51/57 (89.47%)	IL18;HSPD1;RAB1A;...
Mucin type O-glycan biosynthesis	-1.84	1.05e-2	20/36 (55.56%)	GCNT1;C1GALT1C1;GALNT11;...
Rheumatoid arthritis	-1.85	1.03e-2	78/93 (83.87%)	IL1B;ANGPT1;HLA-DRA;...
Amoebiasis	-1.88	9.98e-3	99/102 (97.06%)	PLCB4;ADCY1;IL6;...
TNF signaling pathway	-1.88	1.12e-2	103/112 (91.96%)	LIF;RIPK1;IL6;...
Proximal tubule bicarbonate reclamation	-1.89	1.10e-2	21/23 (91.3%)	CA2;ATP1B2;GLS;...
Carbohydrate digestion and absorption	-1.89	1.28e-2	37/47 (78.72%)	SLC2A5;SLC2A2;CACNA1D;...
Galactose metabolism	-1.90	1.28e-2	26/31 (83.87%)	HKDC1;MGAM;SI;...
Complement and coagulation cascades	-1.97	0.00e+0	76/85 (89.41%)	CFI;C4BPA;ITGB2;...
IL-17 signaling pathway	-2.09	0.00e+0	84/94 (89.36%)	CCL11;IL6;MAPK14;...
Viral protein interaction with cytokine and cytokine re...	-2.18	0.00e+0	84/100 (84%)	ACKR3;CSF1;CCR9;...
Other types of O-glycan biosynthesis	-2.19	0.00e+0	29/47 (61.7%)	B4GALT3;C1GALT1C1;GALNT11;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	10uM	6H	Hide ▲

Bone marrow

Neuroblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
SH-SY5Y	CVCL_0019	Homo sapiens	0.04uM - 10uM	24H	Hide ▲
SK-N-SH	CVCL_0531	Homo sapiens	0.04uM - 10uM	24H	Show ▼