Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5YBO1)

• Drug Name: Levalbuterol Drug Info
• Synonyms: Levosalbutamol; 34391-04-3; (R)-salbutamol; Xopenex; R-Salbutamol; R-Albuterol; (r)-(-)-salbutamol; UNII-EDN2NBH5SS; 4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol; EDN2NBH5SS; CHEBI:8746; Levosalbutamol (INN); Levosalbutamol [INN]; (R)-albuterol; m-Xylene-alpha,alpha'-diol, alpha(sup 1)-((tert-butylamino)methyl)-4-hydroxy-, (R)-(-)-; (-)-alpha(sup 1)-(((1,1-Dimethylethyl)amino)methyl)-4-hydroxy-1,3-benzenedimethanol
• Cross-matching ID:
  PubChem CID: 123600
  ChEBI ID: CHEMBL1002
  CAS Number: CAS 34391-04-3
  TTD Drug ID: D02ZJI
  VARIDT Drug ID: DR00051

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Pentose and glucuronate interconversions	2.20	0.00e+0	17/34 (50%)	AKR1B10;UGDH;UGT2B28;...
Steroid hormone biosynthesis	2.02	0.00e+0	43/61 (70.49%)	AKR1C3;CYP3A5;AKR1C1;...
Retinol metabolism	1.98	0.00e+0	41/68 (60.29%)	ALDH1A2;ALDH1A1;CYP3A5;...
Metabolism of xenobiotics by cytochrome P450	1.98	0.00e+0	49/77 (63.64%)	CYP3A5;AKR1C1;UGT2B28;...
Endocrine and other factor-regulated calcium reabsorpti...	1.95	0.00e+0	49/53 (92.45%)	PRKACB;FXYD2;ATP2B1;...
Citrate cycle (TCA cycle)	1.92	0.00e+0	30/30 (100%)	PCK1;IDH2;DLD;...
Bile secretion	1.88	5.34e-3	68/90 (75.56%)	PRKACB;FXYD2;SLC4A4;...
Vasopressin-regulated water reabsorption	1.86	4.68e-3	40/44 (90.91%)	PRKACB;AQP3;GNAS;...
Inflammatory mediator regulation of TRP channels	1.86	4.16e-3	82/98 (83.67%)	PRKACB;PRKCQ;MAP2K6;...
Pyruvate metabolism	1.80	1.50e-2	41/47 (87.23%)	PCK1;PKM;AKR1A1;...
Aldosterone-regulated sodium reabsorption	1.78	2.15e-2	34/37 (91.89%)	FXYD2;SGK1;SCNN1A;...
Gastric acid secretion	1.74	3.33e-2	63/76 (82.89%)	PRKACB;SST;KCNJ15;...
Renin secretion	1.72	4.12e-2	61/69 (88.41%)	PRKACB;GNAI1;GNAS;...
Butanoate metabolism	1.71	3.83e-2	23/28 (82.14%)	ALDH5A1;HMGCS2;EHHADH;...
Ascorbate and aldarate metabolism	1.70	4.41e-2	15/30 (50%)	UGDH;UGT2B28;AKR1A1;...
Glycolysis / Gluconeogenesis	1.68	4.91e-2	56/67 (83.58%)	PCK1;PKM;PGAM1;...
Long-term depression	1.68	4.77e-2	55/60 (91.67%)	GNAI1;GRIA2;GNAS;...
Ribosome	-1.83	2.43e-2	113/158 (71.52%)	RPS29;RPL21;RPLP0;...
RNA polymerase	-1.84	4.17e-2	23/31 (74.19%)	POLR1E;POLR3B;POLR2L;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	3H, 24H	Hide ▲

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼