Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5YF4M)

• Drug Name: Droxidopa Drug Info
• Synonyms: droxidopa; 23651-95-8; L-DOPS; Northera; (2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid; threo-Dopaserine; 3916-18-5; DOPS; DL-threo-DOPS; L-Threodops; DL-threo-3,4-Dihydroxyphenylserine; DL-threo-Droxidopa; DL-threo-Dihydroxyphenylserine; UNII-J7A92W69L7; SM 5688; CHEBI:31524; Droxidopa (L-DOPS); threo-beta,3-Dihydroxy-DL-tyrosine; EINECS 223-480-5; beta,3-Dihydroxy-DL-tyrosine threo-; BRN 2852792; L-threo-dihydroxyphenylserine; DL-threo-3-(3,4-Dihydroxyphenyl)serine; Serine, 3-(3,4-dihydroxyphenyl)-, DL-threo-
• Cross-matching ID:
  PubChem CID: 92974
  ChEBI ID: CHEMBL2103827
  CAS Number: CAS 23651-95-8
  TTD Drug ID: D0I3RO
  INTEDE Drug ID: DR0552
  ACDINA Drug ID: D00219

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Phagosome	1.93	1.05e-2	118/152 (77.63%)	THBS1;HLA-DRA;HLA-DPA1;...
NF-kappa B signaling pathway	-1.75	4.56e-2	90/104 (86.54%)	ZAP70;TRAF1;TICAM1;...
Chemokine signaling pathway	-1.78	3.33e-2	163/192 (84.9%)	CCR5;ADCY2;CXCR3;...
TNF signaling pathway	-1.82	2.85e-2	103/112 (91.96%)	PIK3CA;BIRC2;LTA;...
Cytokine-cytokine receptor interaction	-2.14	0.00e+0	246/295 (83.39%)	IL5;TNFRSF10D;CCR5;...
Viral protein interaction with cytokine and cytokine re...	-2.33	0.00e+0	84/100 (84%)	TNFRSF10D;CCR5;CXCR3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲