Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM5ZAS6)

Drug Name
Pyrrolidine dithiocarbamate Drug Info
Synonyms
Pyrrolidine dithiocarbamate; Pyrrolidine-1-carbodithioic acid; Pyrrolidine dithiocarbamic acid; Pyrrolidinedithiocarbamate; 1-Pyrrolidinecarbodithioic acid; 25769-03-3; PDTC; apdc; Tetramethylenedithiocarbamic acid; Pyrrolidine-N-carbodithioic acid; Ammonium pyrrolidine dithiocarbamate; 1-Pyrrolidinecarbodithioic acid, ammonium salt; CHEBI:78782; Ammonium 1-pyrrolidinecarbodithioate; C5H9NS2; 5108-96-3; NSC298194; Pyrrolidine-N-dithiocarbamic acid ammonium salt; ammonium tetramethylene dithiocarbamate; NCIOpen2_000025
Cross-matching ID
PubChem CID
65351
ChEBI ID
CHEMBL399491
CAS Number
CAS 25769-03-3
TTD Drug ID
D0B0IJ

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Legionellosis 2.14 9.94e-3 51/57 (89.47%) HSPA1A;CXCL8;HSPA8;...
Mineral absorption 2.02 9.94e-3 48/60 (80%) HMOX1;MT1M;ATP2B1;...
Parkinson disease 1.85 3.98e-2 176/249 (70.68%) TUBB2A;UCHL1;DDIT3;...
Prion disease 1.84 3.48e-2 209/273 (76.56%) HSPA1A;HSPA8;TUBB2A;...
Proteasome 1.81 4.18e-2 44/46 (95.65%) PSMD11;PSMA6;PSMB4;...
Rheumatoid arthritis 1.81 3.48e-2 78/93 (83.87%) CXCL8;MMP3;ATP6V1C1;...
Fluid shear stress and atherosclerosis 1.78 4.69e-2 123/139 (88.49%) HMOX1;NQO1;TXN;...
IL-17 signaling pathway 1.77 4.10e-2 84/94 (89.36%) CXCL8;FOSL1;LCN2;...
Pertussis 1.74 4.64e-2 64/76 (84.21%) CXCL8;CALML3;MAPK13;...
Ferroptosis 1.72 4.97e-2 36/41 (87.8%) HMOX1;SLC7A11;GCLM;...
Pathways of neurodegeneration 1.70 4.97e-2 354/475 (74.53%) TUBB2A;NEFH;WNT5A;...
Drug metabolism -1.75 4.47e-2 78/151 (51.66%) GSTK1;CYP3A4;GSTM2;...
Fatty acid biosynthesis -1.76 4.54e-2 16/18 (88.89%) HSD17B8;ACACA;CBR4;...
Linoleic acid metabolism -1.83 3.02e-2 21/29 (72.41%) CYP3A4;PLA2G1B;CYP2C9;...
Pyruvate metabolism -1.86 3.02e-2 41/47 (87.23%) ADH7;ACACA;ALDH7A1;...
Fatty acid degradation -1.89 2.35e-2 40/43 (93.02%) ACAA1;GCDH;CPT2;...
Regulation of lipolysis in adipocytes -1.94 1.51e-2 52/55 (94.55%) PIK3R3;PRKG1;ADCY6;...
Valine, leucine and isoleucine degradation -2.06 2.02e-2 42/48 (87.5%) ACAA1;OXCT1;HADHA;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H