Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM625WM)

• Drug Name: Ganetespib Drug Info
• Cross-matching ID:
  PubChem CID: 135564985
  ChEBI ID: CHEMBL2103879
  CAS Number: CAS 888216-25-9
  TTD Drug ID: D0I1QI

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Protein processing in endoplasmic reticulum	2.03	0.00e+0	127/171 (74.27%)	HSPA1A;HSPH1;HSPA8;...
C-type lectin receptor signaling pathway	-1.67	4.52e-2	93/104 (89.42%)	NFATC1;SYK;PYCARD;...
Nicotine addiction	-1.68	4.70e-2	32/40 (80%)	GRIA4;GABRG2;GRIN1;...
TNF signaling pathway	-1.69	4.22e-2	103/112 (91.96%)	FADD;CXCL3;RPS6KA4;...
Osteoclast differentiation	-1.69	4.40e-2	117/127 (92.13%)	LILRA4;NFATC1;SYK;...
IL-17 signaling pathway	-1.71	4.01e-2	84/94 (89.36%)	TRAF3IP2;FADD;CXCL3;...
Th17 cell differentiation	-1.73	3.57e-2	95/107 (88.79%)	NFATC1;PPP3CA;NFKBIA;...
Influenza A	-1.73	3.55e-2	156/172 (90.7%)	CASP8;IL1B;EIF2S1;...
Proteasome	-1.76	2.77e-2	44/46 (95.65%)	PSMB6;PSMB3;PSMD9;...
Epstein-Barr virus infection	-1.79	1.98e-2	189/202 (93.56%)	CCND1;PSMC6;CALR;...
Th1 and Th2 cell differentiation	-1.82	8.97e-3	80/92 (86.96%)	HLA-DOB;CD247;IL4R;...
Allograft rejection	-1.84	9.96e-3	32/38 (84.21%)	HLA-DOB;GZMB;HLA-B;...
Graft-versus-host disease	-1.85	1.12e-2	32/42 (76.19%)	IL1B;HLA-DOB;IL1A;...
Leishmaniasis	-1.85	1.28e-2	67/77 (87.01%)	IL1B;HLA-DOB;IL1A;...
Pyrimidine metabolism	-1.86	1.28e-2	40/56 (71.43%)	DHODH;NT5E;CAD;...
Homologous recombination	-1.89	1.02e-2	35/41 (85.37%)	TOPBP1;RAD54B;BARD1;...
Fanconi anemia pathway	-2.00	0.00e+0	36/54 (66.67%)	FAN1;MLH1;FANCE;...
Base excision repair	-2.06	0.00e+0	29/33 (87.88%)	NEIL3;MUTYH;MBD4;...
Mismatch repair	-2.07	0.00e+0	22/23 (95.65%)	SSBP1;MLH1;MSH6;...
DNA replication	-2.36	0.00e+0	34/36 (94.44%)	POLD3;POLD1;RPA2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Hide ▲

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Hide ▲

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼