Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM62T1C)

Drug Name
GW-311616 Drug Info
Synonyms
XVDWNSFFSMWXJJ-BDRHRQAXSA-N; UNII-HN0T99OO4V component XVDWNSFFSMWXJJ-BDRHRQAXSA-N; N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl) ethyl]amino]methyl]phenyl]-2E-2-propenamide D-(-)-lactate salt; n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide d-(-)-lactate salt
Cross-matching ID
PubChem CID
9800961
CAS Number
CAS 198062-54-3
TTD Drug ID
D0Q9UO

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Intestinal immune network for IgA production -1.73 4.07e-2 38/48 (79.17%) ICOS;CXCR4;CCR9;...
Glycosaminoglycan degradation -1.76 3.44e-2 19/19 (100%) ARSB;HYAL2;IDS;...
Lysosome -1.77 3.44e-2 115/128 (89.84%) ATP6V0A1;NPC1;AGA;...
Ferroptosis -1.83 1.72e-2 36/41 (87.8%) ACSL3;GPX4;CYBB;...
Glycosaminoglycan biosynthesis -1.83 2.06e-2 40/58 (68.97%) CHPF;CHST12;CHPF2;...
Sulfur metabolism -1.84 2.01e-2 9/10 (90%) PAPSS2;SQOR;SELENBP1;...
Primary immunodeficiency -1.97 0.00e+0 33/38 (86.84%) PTPRC;CIITA;ICOS;...
Hematopoietic cell lineage -1.97 0.00e+0 90/99 (90.91%) CD37;ITGA1;ITGB3;...
Porphyrin and chlorophyll metabolism -1.98 0.00e+0 23/43 (53.49%) HCCS;UGT2B17;UGT2A3;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H