Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM62UG5)

• Drug Name: Vemurafenib Drug Info
• Synonyms: PLX4032; RG7204; RO5185426; Zelboraf (TN); Vemurafenib (BRAF inhibitor)
• Cross-matching ID:
  PubChem CID: 42611257
  ChEBI ID: CHEMBL63637
  CAS Number: CAS 918504-65-1
  TTD Drug ID: D0Y9EW
  VARIDT Drug ID: DR00711
  INTEDE Drug ID: DR1677
  ACDINA Drug ID: D00723

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Glycine, serine and threonine metabolism	2.27	0.00e+0	31/40 (77.5%)	PSAT1;PHGDH;SHMT2;...
Cysteine and methionine metabolism	2.22	0.00e+0	43/50 (86%)	PSAT1;PHGDH;CBS;...
Alanine, aspartate and glutamate metabolism	2.01	0.00e+0	27/37 (72.97%)	ASNS;ASS1;GOT1;...
One carbon pool by folate	1.85	2.36e-2	15/20 (75%)	SHMT2;MTHFD2;MTHFD1;...
Ribosome	1.79	2.96e-2	113/158 (71.52%)	RSL24D1;MRPS16;MRPL15;...
Fanconi anemia pathway	1.79	2.47e-2	36/54 (66.67%)	USP1;RMI1;FANCG;...
Homologous recombination	1.77	2.40e-2	35/41 (85.37%)	BABAM2;NBN;RBBP8;...
ECM-receptor interaction	-1.70	1.68e-2	80/88 (90.91%)	ITGB8;LAMB3;DSPP;...
Complement and coagulation cascades	-1.71	1.52e-2	76/85 (89.41%)	F5;C1QA;MASP1;...
Leishmaniasis	-1.72	1.48e-2	67/77 (87.01%)	MARCKSL1;HLA-DOB;HLA-DRA;...
Hepatitis C	-1.73	1.48e-2	139/157 (88.54%)	TRADD;RSAD2;ARAF;...
Lysosome	-1.73	1.54e-2	115/128 (89.84%)	CLN3;HYAL2;HYAL1;...
Vibrio cholerae infection	-1.74	1.55e-2	44/50 (88%)	PLCG2;ATP6V1B2;KCNQ1;...
Allograft rejection	-1.74	1.44e-2	32/38 (84.21%)	IL5;IL10;HLA-E;...
B cell receptor signaling pathway	-1.74	1.51e-2	71/81 (87.65%)	PLCG2;AKT1;NFATC3;...
Small cell lung cancer	-1.77	1.15e-2	90/92 (97.83%)	CCND1;CHUK;E2F1;...
Pertussis	-1.78	8.89e-3	64/76 (84.21%)	NFKB1;RHOA;CALML5;...
NF-kappa B signaling pathway	-1.78	9.33e-3	90/104 (86.54%)	TRADD;NFKB1;DDX58;...
Rheumatoid arthritis	-1.82	4.21e-3	78/93 (83.87%)	ATP6V1A;ATP6V0A1;HLA-DOB;...
Toxoplasmosis	-1.84	4.44e-3	103/112 (91.96%)	IKBKB;GNAI3;CASP3;...
Inflammatory bowel disease	-1.86	3.14e-3	58/65 (89.23%)	IL5;TLR2;IL10;...
Chagas disease	-1.87	2.50e-3	93/102 (91.18%)	TGFBR2;NFKB1;C1QB;...
Toll-like receptor signaling pathway	-1.87	2.67e-3	94/104 (90.38%)	IRAK1;AKT1;RIPK1;...
Hematopoietic cell lineage	-1.89	2.86e-3	90/99 (90.91%)	GP1BB;CD1C;CD22;...
Measles	-1.90	3.08e-3	133/139 (95.68%)	CCND1;CHUK;IL6;...
Influenza A	-1.91	2.22e-3	156/172 (90.7%)	NXF2;CHUK;PYCARD;...
Biosynthesis of unsaturated fatty acids	-1.93	2.42e-3	21/27 (77.78%)	SCD5;ACOX3;HACD3;...
Staphylococcus aureus infection	-1.95	2.67e-3	72/95 (75.79%)	C1QA;MASP1;FCGR2C;...
Salmonella infection	-1.99	2.96e-3	198/249 (79.52%)	RIPK1;HSP90AB1;DCTN6;...
Malaria	-2.00	1.67e-3	44/50 (88%)	TGFB2;TLR4;CD81;...
Terpenoid backbone biosynthesis	-2.01	1.90e-3	18/22 (81.82%)	HMGCR;MVD;FDPS;...
Herpes simplex virus 1 infection	-2.01	2.22e-3	165/498 (33.13%)	TRADD;NFKB1;SRSF5;...
Epstein-Barr virus infection	-2.07	2.67e-3	189/202 (93.56%)	NFKBIE;CCND1;CHUK;...
Legionellosis	-2.13	0.00e+0	51/57 (89.47%)	TLR4;NFKB2;IL1B;...
Antigen processing and presentation	-2.25	0.00e+0	60/78 (76.92%)	CD4;PSME2;CD8B;...
Phagosome	-2.44	0.00e+0	118/152 (77.63%)	HLA-E;M6PR;FCGR2C;...
Steroid biosynthesis	-2.61	0.00e+0	19/20 (95%)	SOAT1;HSD17B7;TM7SF2;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Ewing sarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-673	CVCL_0080	Homo sapiens	10uM	6H	Hide ▲
SK-ES-1	CVCL_0627	Homo sapiens	0.12uM - 10uM	24H	Hide ▲
TC-32	CVCL_7141	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	0.12uM - 10uM	6H, 24H, 48H	Show ▼

Brain

Glioblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-251 MG	CVCL_0021	Homo sapiens	0.12uM - 10uM	24H	Show ▼
YH-13	CVCL_1800	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Glioma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
GI-1	CVCL_1230	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H, 48H	Show ▼
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H	Show ▼
MDA-MB-468	CVCL_0419	Homo sapiens	0.12uM - 10uM	24H	Show ▼
SK-BR-3	CVCL_0033	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H	Show ▼

Breast carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BT-20	CVCL_0178	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H	Show ▼
Hs 578T	CVCL_0332	Homo sapiens	0.04uM - 10uM	3H, 6H, 24H	Show ▼

Breast ductal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BT-474	CVCL_0179	Homo sapiens	0.12uM - 10uM	24H	Show ▼
T-47D	CVCL_0553	Homo sapiens	0.12uM - 10uM	24H	Show ▼
ZR-75-1	CVCL_0588	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	3H, 6H, 24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
CL-34	CVCL_1123	Homo sapiens	10uM	6H	Show ▼
GP2d	CVCL_1234	Homo sapiens	0.12uM - 10uM	24H	Show ▼
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
LoVo	CVCL_0399	Homo sapiens	10uM	6H	Show ▼
MDST8	CVCL_1400	Homo sapiens	10uM	6H	Show ▼
NCI-H508	CVCL_1561	Homo sapiens	10uM	6H	Show ▼
SNU-1040	CVCL_5001	Homo sapiens	10uM	6H	Show ▼
SNU-407	CVCL_5004	Homo sapiens	0.12uM - 10uM	24H	Show ▼
SNU-C4	CVCL_5008	Homo sapiens	10uM	6H	Show ▼
SNU-C5	CVCL_5009	Homo sapiens	10uM	6H	Show ▼
SW480	CVCL_0546	Homo sapiens	10uM	6H	Show ▼
SW620	CVCL_0547	Homo sapiens	10uM	6H	Show ▼
SW948	CVCL_0550	Homo sapiens	10uM	6H	Show ▼

Colorectal carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCT 116	CVCL_0291	Homo sapiens	10uM	6H	Show ▼
HT115	CVCL_1294	Homo sapiens	10uM	6H	Show ▼
RKO	CVCL_0504	Homo sapiens	10uM	6H	Show ▼

Embryonic stem cell

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
WA09 (H9) Derived	CVCL_9773 (WA09)	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Endometrium

Endometrial adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEC-108	CVCL_2926	Homo sapiens	1.11uM - 10uM	6H, 24H	Show ▼
HEC-151	CVCL_2927	Homo sapiens	0.12uM - 10uM	24H	Show ▼
HEC-1-A	CVCL_0293	Homo sapiens	0.12uM - 10uM	24H	Show ▼
HEC-251	CVCL_2928	Homo sapiens	0.12uM - 10uM	24H	Show ▼
HEC-265	CVCL_2929	Homo sapiens	0.12uM - 10uM	24H	Show ▼
SNG-M	CVCL_1707	Homo sapiens	10uM	6H	Show ▼

Endometrial carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
JHUEM-2	CVCL_1327	Homo sapiens	10uM	6H	Show ▼

Hematopoietic system

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ASC	CVCL_U602	Homo sapiens	10uM	24H	Show ▼
CJM	CVCL_U797	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Renal cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
RCC10RGB	CVCL_1656	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Rhabdoid tumor

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
G-401	CVCL_0270	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Liver

Hepatoblastoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Hep G2	CVCL_0027	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
JHH-5	CVCL_1320	Homo sapiens	0.12uM - 10uM	24H	Show ▼
JHH-7	CVCL_1322	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	6H, 24H, 48H	Show ▼
DV-90	CVCL_1184	Homo sapiens	10uM	6H	Show ▼
NCI-H1437	CVCL_1472	Homo sapiens	0.12uM - 10uM	24H	Show ▼
NCI-H1573	CVCL_1483	Homo sapiens	0.12uM - 10uM	24H	Show ▼
NCI-H838	CVCL_1594	Homo sapiens	0.12uM - 10uM	24H	Show ▼
SK-LU-1	CVCL_0624	Homo sapiens	10uM	6H	Show ▼

Lung adenosquamous carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NCI-H596	CVCL_1571	Homo sapiens	10uM	6H	Show ▼

Lung large cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
COR-L23	CVCL_1133	Homo sapiens	10uM	6H	Show ▼

Lung squamous cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BEN	CVCL_1081	Homo sapiens	0.12uM - 10uM	24H	Show ▼
HCC15	CVCL_1253	Homo sapiens	10uM	6H	Show ▼
HCC1588	CVCL_1263	Homo sapiens	0.12uM - 10uM	24H	Show ▼
HCC95	CVCL_1276	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NCI-H1299	CVCL_0060	Homo sapiens	10uM	6H	Show ▼
HCC515	CVCL_5134	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼
NCI-H2073	CVCL_1523	Homo sapiens	10uM	6H	Show ▼
NCI-H2110	CVCL_1529	Homo sapiens	0.12uM - 10uM	24H	Show ▼
NCI-H2172	CVCL_1534	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NCI-H1694	CVCL_1495	Homo sapiens	10uM	6H	Show ▼
NCI-H1836	CVCL_1502	Homo sapiens	10uM	6H	Show ▼
NCI-H841	CVCL_1595	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Lymph node

Diffuse large B-cell lymphoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
WSU-DLCL2	CVCL_1787	Homo sapiens	10uM	6H	Show ▼

Muscle

Rhabdomyosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-204	CVCL_0134	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Oral cavity

Oral squamous cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BICR 6	CVCL_1086	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Ovary

Ovarian carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
EFO-27	CVCL_1194	Homo sapiens	10uM	6H	Show ▼
OV7	CVCL_1623	Homo sapiens	10uM	6H	Show ▼
OVK18	CVCL_1629	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Ovarian clear cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
ES-2	CVCL_3509	Homo sapiens	0.12uM - 10uM	24H	Show ▼
OVTOKO	CVCL_3114	Homo sapiens	0.12uM - 10uM	24H	Show ▼
RMG-I	CVCL_1663	Homo sapiens	10uM	6H	Show ▼

Ovarian cystadenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
OAW 28	CVCL_1611	Homo sapiens	0.12uM - 10uM	24H	Show ▼
OC 316	CVCL_1615	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Ovarian endometrioid carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
TOV-112D	CVCL_3612	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Ovarian granulosa cell tumor

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
COV434	CVCL_2010	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Ovarian mucinous cystadenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
COV644	CVCL_2011	Homo sapiens	10uM	6H	Show ▼
RMUG-S	CVCL_1666	Homo sapiens	10uM	6H	Show ▼

Ovarian undifferentiated carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
TYK-nu	CVCL_1774	Homo sapiens	10uM	6H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.04uM - 10uM	6H, 24H	Show ▼

Acute myeloid leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
NOMO-1	CVCL_1609	Homo sapiens	10uM	6H	Show ▼
PL-21	CVCL_2161	Homo sapiens	10uM	6H	Show ▼
SKM-1	CVCL_0010	Homo sapiens	10uM	6H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Pleural effusion

Histiocytic lymphoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-937	CVCL_0007	Homo sapiens	10uM	6H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
22Rv1	CVCL_1045	Homo sapiens	0.12uM - 10uM	24H	Show ▼
LNCaP clone FGC	CVCL_1379	Homo sapiens	0.12uM - 10uM	24H	Show ▼
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
VCaP	CVCL_2235	Homo sapiens	10uM	6H, 24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	6H, 24H	Show ▼
IGR-37	CVCL_1303	Homo sapiens	0.12uM - 10uM	24H	Show ▼
Mel-HO	CVCL_1402	Homo sapiens	0.12uM - 10uM	24H	Show ▼
SH-4	CVCL_1692	Homo sapiens	0.12uM - 10uM	24H	Show ▼
SK-MEL-1	CVCL_0523	Homo sapiens	10uM	6H	Show ▼
SK-MEL-28	CVCL_0526	Homo sapiens	10uM	6H	Show ▼
SK-MEL-3	CVCL_0525	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Stomach

Gastric adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
AGS	CVCL_0139	Homo sapiens	0.12uM - 10uM	6H, 24H	Show ▼
MKN45	CVCL_0434	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Gastric carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
IM95	CVCL_1305	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Urinary bladder

Bladder carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
BC-3C	CVCL_1079	Homo sapiens	0.12uM - 10uM	24H	Show ▼

Bladder transitional cell carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
CAL-29	CVCL_1109	Homo sapiens	0.12uM - 10uM	24H	Show ▼