Details of the Drug Pharmacogenomic Perturbation Atlas

Fluocinonide Drug Info

Bestasone; Biscosal; Cortalar; Fluocinolide; Fluocinonido; Fluocinonidum; Fluonex; Fluzon; Lidex; Lonide; Lyderm;Metosyn; Straderm; Topsymin; Topsyn; Vanos; Fluocinolide acetate; Fluocinolone acetonide acetate; Fluocinonide Emulsified Base; Fluocinonide FAPG; Lidex E; Synalar acetate; Fluocinolone acetonide 21-acetate; Fluocinonido [INN-Spanish]; Fluocinonidum [INN-Latin]; Fluonex (TN); LIDEX (TN); LIDEX-E; Lidex (TN); Lonide (TN); Lyderm (TN); Vanos (TN); Lidex-E (TN); Fluocinonide (JP15/USP/INN); Fluocinonide [USAN:BAN:INN:JAN]; Fluocinonide [USAN:INN:BAN:JAN]; Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone, 21-acetate; Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone, 21-acetate (8CI); Pregna-1,4-diene-3,20-dione, 6-alpha, 9-difluoro-11-beta,16-alpha,17,21-tetrahydroxy-, cyclic17-acetal with acetone, 21-acetate; 6alpha,9-Difluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone, 21-acetate

Therapeutic Class

Antiinflammatory Agents

Cross-matching ID

PubChem CID

9642

ChEBI ID

CHEMBL1501

CAS Number

CAS 356-12-7

TTD Drug ID

D03ZZK

INTEDE Drug ID

DR0714

ACDINA Drug ID

D01090

General Information of Drug (ID: DM65KL8)

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Nitrogen metabolism	2.11	0.00e+0	16/17 (94.12%)	GLUL;CA2;CA12;...
DNA replication	1.99	1.38e-2	34/36 (94.44%)	FEN1;POLE;POLD2;...
Histidine metabolism	1.94	1.85e-2	16/22 (72.73%)	MAOB;ASPA;MAOA;...
Proximal tubule bicarbonate reclamation	1.91	1.85e-2	21/23 (91.3%)	CA2;SLC4A4;ATP1A2;...
Linoleic acid metabolism	1.89	1.85e-2	21/29 (72.41%)	PLAAT3;CYP2E1;CYP2C9;...
Alanine, aspartate and glutamate metabolism	1.87	1.69e-2	27/37 (72.97%)	GLUL;CPS1;ASPA;...
Bile secretion	1.82	2.64e-2	68/90 (75.56%)	CA2;AQP9;SLC4A4;...
Drug metabolism	1.77	3.92e-2	78/151 (51.66%)	MAOB;CYP2E1;MAOA;...
Protein digestion and absorption	1.76	3.49e-2	78/103 (75.73%)	COL1A2;COL1A1;COL3A1;...
Fatty acid degradation	1.74	3.51e-2	40/43 (93.02%)	ACSL1;ADH5;ALDH2;...
Base excision repair	1.70	4.45e-2	29/33 (87.88%)	HMGB1;FEN1;PARP2;...
Platelet activation	1.70	4.07e-2	106/124 (85.48%)	COL1A2;COL1A1;COL3A1;...
Arginine biosynthesis	1.69	4.12e-2	17/22 (77.27%)	GLUL;CPS1;ASS1;...
Complement and coagulation cascades	1.69	4.15e-2	76/85 (89.41%)	VWF;F13A1;CFD;...
Arachidonic acid metabolism	1.65	4.83e-2	48/61 (78.69%)	PLAAT3;ALOX5;CYP2E1;...
Graft-versus-host disease	-1.84	2.15e-2	32/42 (76.19%)	IL1A;HLA-A;TNF;...
Steroid biosynthesis	-1.86	1.88e-2	19/20 (95%)	LSS;TM7SF2;CYP27B1;...
IL-17 signaling pathway	-1.89	2.15e-2	84/94 (89.36%)	CCL11;TBK1;IKBKG;...
Type I diabetes mellitus	-1.95	0.00e+0	38/43 (88.37%)	PTPRN;IL1A;HLA-A;...
Rheumatoid arthritis	-1.99	0.00e+0	78/93 (83.87%)	ATP6V0D1;IL1B;HLA-DQB1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Bone

Osteosarcoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
U-2 OS	CVCL_0042	Homo sapiens	4uM	6H

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	10uM	6H, 24H

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	10uM	6H

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	10uM	6H

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	10uM	6H, 24H

Non-small cell lung carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HCC515	CVCL_5134	Homo sapiens	10uM	6H

Prostate

Prostate carcinoma

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	10uM	6H