Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM67PWD)

Drug Name
Etilefrine Drug Info
Synonyms
etilefrine hydrochloride; 943-17-9; Etilefrine HCl; Circupon; Kertasin; Effontil; 534-87-2; 3-[2-(ethylamino)-1-hydroxyethyl]phenol hydrochloride; Effortilvet; Phetasin; Updormin; Pulsamin; Apocretin; Phetanol; Funasol; Ethyl adrianol; Tonus-Forte; Etilefrin Hydrochloride; Eti-Puren; 3-(2-(Ethylamino)-1-hydroxyethyl)phenol hydrochloride; 2-Ethylamino-1-(3-hydroxyphenyl)ethanol Hydrochloride; Etilefrine hydrochloride (TN); dl-Effortil hydrochloride; Ethylephrine hydrochloride; dl-Etilefrin hydrochloride; dl-N-Ethylnorphenylephrine h
Cross-matching ID
PubChem CID
3306
ChEBI ID
CHEMBL86882
CAS Number
CAS 709-55-7
TTD Drug ID
D01MXV
VARIDT Drug ID
DR00028

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
DNA replication 2.09 6.47e-3 34/36 (94.44%) MCM5;FEN1;POLA2;...
Fanconi anemia pathway 1.99 3.24e-3 36/54 (66.67%) FANCI;RAD51C;CENPX;...
Homologous recombination 1.97 2.16e-3 35/41 (85.37%) RAD51C;BARD1;RAD51;...
Ribosome biogenesis in eukaryotes 1.93 3.24e-3 52/108 (48.15%) IMP3;NHP2;POP5;...
RNA polymerase 1.79 1.42e-2 23/31 (74.19%) POLR3B;POLR2I;POLR2F;...
Mismatch repair 1.75 2.70e-2 22/23 (95.65%) MSH6;EXO1;RFC2;...
Cell cycle 1.68 4.99e-2 110/124 (88.71%) CDC45;MCM5;GADD45G;...
Morphine addiction -1.78 4.07e-2 80/91 (87.91%) PDE7B;GNG7;DRD1;...
Steroid hormone biosynthesis -1.78 4.47e-2 43/61 (70.49%) AKR1C4;CYP11B1;CYP7A1;...
PPAR signaling pathway -1.79 4.50e-2 66/74 (89.19%) FADS2;ILK;ADIPOQ;...
Serotonergic synapse -1.83 2.62e-2 97/114 (85.09%) PRKACA;ALOX15B;RAF1;...
Steroid biosynthesis -1.86 2.40e-2 19/20 (95%) SOAT1;DHCR7;CYP24A1;...
Protein processing in endoplasmic reticulum -1.87 2.56e-2 127/171 (74.27%) SEC23A;SEC61A1;RBX1;...
Bile secretion -1.88 2.80e-2 68/90 (75.56%) SLCO1B1;ABCG5;SLC22A7;...
Tryptophan metabolism -1.94 1.75e-2 35/42 (83.33%) KYNU;ALDH7A1;HADHA;...
Complement and coagulation cascades -2.06 0.00e+0 76/85 (89.41%) CFHR2;MASP1;CFB;...
Nicotine addiction -2.19 0.00e+0 32/40 (80%) CACNA1A;GABRA1;GABRG2;...
Ferroptosis -2.30 0.00e+0 36/41 (87.8%) PCBP2;FTH1;GPX4;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H, 24H