Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM67VKL)

Drug Name
Prasterone Drug Info
Synonyms
Dehydroepiandrosterone; DHEA; 53-43-0; PRASTERONE; Dehydroisoandrosterone; Androstenolone; trans-Dehydroandrosterone; Psicosterone; Diandrone; Diandron; 3beta-hydroxyandrost-5-en-17-one; 17-Hormoforin; Prestara; 17-Chetovis; Andrestenol; 5-Dehydroepiandrosterone; Intrarosa; Siscelar plus; 5,6-Didehydroisoandrosterone; Dehydro-epi-androsterone; Prasteronum; 5,6-Dehydroisoandrosterone; Prasterona; Epiandrosterone, 5-dehydro-; Caswell No 051F; 5,6-Dehydroisoandrostorone
Cross-matching ID
PubChem CID
5881
ChEBI ID
CHEMBL28689
CAS Number
CAS 53-43-0
TTD Drug ID
D0K0EK
VARIDT Drug ID
DR01193
INTEDE Drug ID
DR0431

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Mitophagy 1.81 1.70e-1 56/68 (82.35%) KRAS;SRC;MITF;...
Renin secretion 1.80 9.94e-2 61/69 (88.41%) KCNJ2;ADRB2;GNAI1;...
Graft-versus-host disease 1.76 9.15e-2 32/42 (76.19%) GZMB;PRF1;IL6;...
Allograft rejection 1.71 1.33e-1 32/38 (84.21%) GZMB;PRF1;HLA-B;...
Mineral absorption 1.65 1.87e-1 48/60 (80%) STEAP1;MT1E;MT1F;...
Type I diabetes mellitus 1.65 1.56e-1 38/43 (88.37%) GZMB;PRF1;HLA-B;...
Bladder cancer 1.65 1.37e-1 40/41 (97.56%) FGFR3;E2F2;CXCL8;...
Sulfur relay system 1.64 1.27e-1 5/8 (62.5%) TST;MPST;MOCS2;...
Tyrosine metabolism 1.62 1.40e-1 30/36 (83.33%) ALDH3A1;COMT;TYRP1;...
Vasopressin-regulated water reabsorption 1.60 1.54e-1 40/44 (90.91%) AQP3;CREB3L1;DYNC2LI1;...
Viral protein interaction with cytokine and cytokine re... 1.59 1.46e-1 84/100 (84%) TNFSF10;CXCL8;CXCL9;...
Glutathione metabolism 1.58 1.42e-1 43/57 (75.44%) GSTP1;GSTA4;GCLC;...
Primary bile acid biosynthesis 1.57 1.48e-1 15/17 (88.24%) AMACR;ACOX2;CH25H
Glycine, serine and threonine metabolism 1.55 1.57e-1 31/40 (77.5%) PGAM1;PSAT1;CBS;...
Fluid shear stress and atherosclerosis 1.53 1.77e-1 123/139 (88.49%) BMP4;THBD;SELE;...
Thiamine metabolism 1.53 1.67e-1 12/15 (80%) AK4;ACP1;AK1;...
Circadian rhythm 1.50 1.86e-1 26/31 (83.87%) BHLHE41;PER2;RORA;...
Kaposi sarcoma-associated herpesvirus infection 1.48 2.10e-1 172/193 (89.12%) E2F2;CXCL8;KRAS;...
Phenylalanine metabolism 1.47 2.11e-1 14/17 (82.35%) ALDH3A1;ALDH3B1;GLYAT;...
Metabolism of xenobiotics by cytochrome P450 1.46 2.22e-1 49/77 (63.64%) ALDH3A1;GSTP1;GSTA4;...
Cysteine and methionine metabolism 1.45 2.21e-1 43/50 (86%) GCLC;BCAT1;PSAT1;...
Autoimmune thyroid disease 1.41 3.10e-1 46/53 (86.79%) GZMB;PRF1;HLA-B;...
Melanogenesis 1.40 3.10e-1 74/101 (73.27%) FZD6;KRAS;MITF;...
Salivary secretion 1.40 2.99e-1 76/93 (81.72%) SLC12A2;CST3;ADRB2;...
Amoebiasis 1.40 2.95e-1 99/102 (97.06%) COL4A5;CXCL8;CD1C;...
Nucleotide excision repair 1.37 3.34e-1 40/47 (85.11%) CETN2;MNAT1;POLE3;...
Parkinson disease 1.37 3.25e-1 176/249 (70.68%) DAXX;UCHL1;TUBB2A;...
Cortisol synthesis and secretion 1.36 3.33e-1 58/65 (89.23%) NR4A1;CREB3L1;AGTR1;...
Sulfur metabolism 1.35 3.23e-1 9/10 (90%) SELENBP1;TST;SUOX;...
Primary immunodeficiency 1.34 3.37e-1 33/38 (86.84%) IL7R;CD3E;CD8A;...
Nicotinate and nicotinamide metabolism -1.30 4.10e-1 25/35 (71.43%) SIRT3;NT5C;SIRT2;...
Aminoacyl-tRNA biosynthesis -1.31 4.03e-1 15/66 (22.73%) IARS2
Protein digestion and absorption -1.32 3.88e-1 78/103 (75.73%) SLC15A1;COL2A1;COL4A2;...
Tuberculosis -1.37 2.98e-1 159/180 (88.33%) CLEC4M;IL12B;FCGR2C;...
Adipocytokine signaling pathway -1.37 3.05e-1 64/69 (92.75%) ADIPOR1;MTOR;PRKAB2;...
Fatty acid degradation -1.37 3.09e-1 40/43 (93.02%) ACSL6;ALDH3A2;ADH5;...
ECM-receptor interaction -1.38 3.00e-1 80/88 (90.91%) SV2A;HSPG2;ITGA5;...
AMPK signaling pathway -1.38 3.09e-1 106/120 (88.33%) PPP2R5B;PPP2R3B;ADIPOR1;...
Various types of N-glycan biosynthesis -1.39 3.10e-1 26/39 (66.67%) MGAT2;MGAT1;MAN1B1;...
Cholesterol metabolism -1.39 3.19e-1 44/50 (88%) VDAC2;SOAT1;APOA4;...
Neomycin, kanamycin and gentamicin biosynthesis -1.40 3.08e-1 5/5 (100%) HK1;HKDC1;HK3
Pancreatic secretion -1.41 3.05e-1 87/102 (85.29%) PLA2G12A;PNLIPRP2;ATP1A3;...
Fatty acid elongation -1.41 3.13e-1 19/27 (70.37%) HADHA;ACOT7;ELOVL4;...
Focal adhesion -1.42 3.22e-1 180/201 (89.55%) CTNNB1;PIK3CB;LAMA2;...
Glycerolipid metabolism -1.42 3.31e-1 44/61 (72.13%) ALDH9A1;AGPAT2;AGPAT4;...
Biosynthesis of unsaturated fatty acids -1.44 3.25e-1 21/27 (77.78%) ACAA1;HACD2;SCD5;...
Lysosome -1.46 2.97e-1 115/128 (89.84%) NPC1;AP4M1;GALNS;...
Toxoplasmosis -1.47 2.85e-1 103/112 (91.96%) MYD88;LAMB1;TLR2;...
Vitamin digestion and absorption -1.48 2.94e-1 17/24 (70.83%) MMACHC;SLC19A3;APOA4;...
FoxO signaling pathway -1.49 2.89e-1 118/131 (90.08%) PIK3CB;SIRT1;CDK2;...
Prostate cancer -1.49 3.15e-1 93/97 (95.88%) MTOR;TMPRSS2;CTNNB1;...
MicroRNAs in cancer -1.51 3.03e-1 146/310 (47.1%) PIM1;E2F1;PIK3CB;...
Proteoglycans in cancer -1.51 3.26e-1 172/205 (83.9%) CTNNB1;PIK3CB;PPP1R12A;...
Carbohydrate digestion and absorption -1.55 2.58e-1 37/47 (78.72%) AKT2;PIK3CD;PLCB3;...
Notch signaling pathway -1.55 2.90e-1 49/59 (83.05%) MFNG;CTBP1;PSEN2;...
Leishmaniasis -1.56 3.13e-1 67/77 (87.01%) NOS2;MAPK1;FOS;...
Ovarian steroidogenesis -1.57 3.55e-1 41/51 (80.39%) AKR1C3;SCARB1;INS;...
Fat digestion and absorption -1.63 2.60e-1 35/43 (81.4%) FABP2;PLA2G12A;PNLIPRP2;...
Phagosome -1.65 2.94e-1 118/152 (77.63%) CLEC4M;FCGR2C;ATP6V1C1;...
PPAR signaling pathway -1.71 2.66e-1 66/74 (89.19%) DBI;ACSL6;FABP2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 1.25uM - 40uM 3H, 24H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 12uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.04uM - 10uM 24H
Umbilical vein
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HUVEC-C CVCL_2959 Homo sapiens 0.01uM - 10uM 24H