Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM68FSZ)

Drug Name
Zucapsacin Drug Info
Synonyms Civanex (TN)
Cross-matching ID
PubChem CID
1548942
ChEBI ID
CHEMBL313971
CAS Number
CAS 25775-90-0
TTD Drug ID
D03LGG

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Protein digestion and absorption 1.89 3.25e-2 78/103 (75.73%) COL10A1;SLC38A2;COL9A3;...
Ferroptosis -1.78 4.24e-2 36/41 (87.8%) ACSL5;ACSL3;SLC7A11;...
TNF signaling pathway -1.79 4.86e-2 103/112 (91.96%) CEBPB;IKBKB;NFKB1;...
Tyrosine metabolism -1.84 2.89e-2 30/36 (83.33%) ADH6;TYRP1;ALDH3B1;...
Complement and coagulation cascades -1.97 7.71e-3 76/85 (89.41%) PROC;SERPIND1;TFPI;...
Staphylococcus aureus infection -1.98 1.16e-2 72/95 (75.79%) KRT33B;MBL2;KRT24;...
IL-17 signaling pathway -2.01 1.16e-2 84/94 (89.36%) CEBPB;IKBKB;NFKB1;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Ewing sarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-673 CVCL_0080 Homo sapiens 150uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 150uM 6H, 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
CL-34 CVCL_1123 Homo sapiens 150uM 6H
HT-29 CVCL_0320 Homo sapiens 0.01uM - 150uM 6H, 24H
LoVo CVCL_0399 Homo sapiens 150uM 6H
MDST8 CVCL_1400 Homo sapiens 150uM 6H
NCI-H508 CVCL_1561 Homo sapiens 150uM 6H
SNU-1040 CVCL_5001 Homo sapiens 150uM 6H
SNU-C4 CVCL_5008 Homo sapiens 150uM 6H
SNU-C5 CVCL_5009 Homo sapiens 150uM 6H
SW480 CVCL_0546 Homo sapiens 150uM 6H
SW620 CVCL_0547 Homo sapiens 150uM 6H
SW948 CVCL_0550 Homo sapiens 150uM 6H
Colorectal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCT 116 CVCL_0291 Homo sapiens 150uM 6H
HT115 CVCL_1294 Homo sapiens 150uM 6H
RKO CVCL_0504 Homo sapiens 150uM 6H
Endometrium
Endometrial adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEC-108 CVCL_2926 Homo sapiens 150uM 6H
SNG-M CVCL_1707 Homo sapiens 150uM 6H
Endometrial carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
JHUEM-2 CVCL_1327 Homo sapiens 150uM 6H
Fibroblast
Nasopharyngeal carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
FIBRNPC CVCL_UK07 Homo sapiens 10uM 6H, 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 150uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 150uM 6H
Hepatocellular carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HuH-7 CVCL_0336 Homo sapiens 10uM 72H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 150uM 6H, 24H
DV-90 CVCL_1184 Homo sapiens 150uM 6H
SK-LU-1 CVCL_0624 Homo sapiens 150uM 6H
Lung adenosquamous carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H596 CVCL_1571 Homo sapiens 150uM 6H
Lung large cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COR-L23 CVCL_1133 Homo sapiens 150uM 6H
T3M-10 CVCL_1729 Homo sapiens 150uM 6H
Lung squamous cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC15 CVCL_1253 Homo sapiens 150uM 6H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1299 CVCL_0060 Homo sapiens 150uM 6H
HCC515 CVCL_5134 Homo sapiens 150uM 6H, 24H
NCI-H2073 CVCL_1523 Homo sapiens 150uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NCI-H1836 CVCL_1502 Homo sapiens 150uM 6H
Lymph node
Diffuse large B-cell lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
WSU-DLCL2 CVCL_1787 Homo sapiens 150uM 6H
Ovary
Ovarian carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
EFO-27 CVCL_1194 Homo sapiens 150uM 6H
OV7 CVCL_1623 Homo sapiens 150uM 6H
Ovarian clear cell carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
RMG-I CVCL_1663 Homo sapiens 150uM 6H
Ovarian mucinous cystadenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
COV644 CVCL_2011 Homo sapiens 150uM 6H
RMUG-S CVCL_1666 Homo sapiens 150uM 6H
Ovarian undifferentiated carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
TYK-nu CVCL_1774 Homo sapiens 150uM 6H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 150uM 6H, 24H
Acute myeloid leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
NOMO-1 CVCL_1609 Homo sapiens 150uM 6H
PL-21 CVCL_2161 Homo sapiens 150uM 6H
SKM-1 CVCL_0010 Homo sapiens 150uM 6H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Pleural effusion
Histiocytic lymphoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-937 CVCL_0007 Homo sapiens 150uM 6H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 150uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM - 150uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 150uM 6H, 24H
SK-MEL-1 CVCL_0523 Homo sapiens 150uM 6H
SK-MEL-28 CVCL_0526 Homo sapiens 150uM 6H
Stomach
Gastric adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
AGS CVCL_0139 Homo sapiens 150uM 6H