Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM68S9F)

• Drug Name: 4-(DIMETHYLAMINO)BUTYL IMIDOTHIOCARBAMATE Drug Info
• Synonyms: 4-(Dimethylamino)butyl carbamimidothioate; F 91488; UNII-1I4LVX494H; SKF 91488; F-91488; SKF-91488; 1I4LVX494H; 68643-23-2; [4-(carbamimidoylsulfanyl)butyl]dimethylamine; Carbamimidothioic acid, 4-(dimethylamino)butyl ester; 4DI; Tocris-0512; Lopac-S-145; AC1L1JVO; AC1Q1UAN; Lopac0_001172; carbamimidothioic acid 4-(dimethylamino)butyl ester; CHEMBL1230270; SCHEMBL12648461; CTK5C8308; ZINC29747245; AKOS006328360; DB07106; CCG-205246; NCGC00024626-01; NCGC00015911-02
• Cross-matching ID:
  PubChem CID: 5227
  CAS Number: CAS 68643-23-2
  TTD Drug ID: D0F0ZX

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Steroid biosynthesis	-1.69	4.72e-2	19/20 (95%)	DHCR24;SOAT2;LBR;...
Complement and coagulation cascades	-1.86	1.24e-2	76/85 (89.41%)	SERPINC1;SERPING1;CFI;...
Ferroptosis	-1.89	1.18e-2	36/41 (87.8%)	ALOX15;ACSL5;SLC3A2;...
Staphylococcus aureus infection	-1.95	3.54e-3	72/95 (75.79%)	MBL2;PTAFR;FGG;...
Bile secretion	-1.99	0.00e+0	68/90 (75.56%)	ABCC4;ABCB1;ABCB11;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	1.11uM - 10uM	24H	Hide ▲

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	1.11uM - 10uM	24H	Hide ▲