Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6AN32)

• Drug Name: Trovafloxacin Drug Info
• Synonyms: TVFX; Trovan; Fluorinated quinolone; Trovafloxacin [INN]; CP 99219; CP99219; CP 99,219; CP-99219;Trovafloxacin (INN); Trovan (TN); Trovan (oral); Turvel (TN); CP-99,219; (1alpha,5alpha,6alpha)-7-(6-Amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; 7-((1R,5S)-6-Amino-3-aza-bicyclo[3.1.0]hex-3-yl)-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid; 7-[(1R,5S)-6-amino-3-azabicyclo[3.1.0]hexan-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid; 7-[(1R,5S,6s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; 7-[(1r,5s)-6-amino-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• Therapeutic Class: Antiinfective Agents
• Cross-matching ID:
  PubChem CID: 62959
  ChEBI ID: CHEMBL9763
  CAS Number: CAS 147059-72-1
  TTD Drug ID: D03WPA

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
alpha-Linolenic acid metabolism	1.82	3.90e-2	17/25 (68%)	PLAAT3;PLA2G12A;PLA2G4C;...
Carbohydrate digestion and absorption	-1.67	4.82e-2	37/47 (78.72%)	SLC2A2;ATP1B3;SI;...
African trypanosomiasis	-1.68	4.65e-2	32/37 (86.49%)	TNF;PLCB3;IL1B;...
Epithelial cell signaling in Helicobacter pylori infect...	-1.69	4.76e-2	62/70 (88.57%)	PTPRZ1;RAC1;CXCL1;...
Primary bile acid biosynthesis	-1.70	4.65e-2	15/17 (88.24%)	HSD17B4;AKR1C4;CYP27A1;...
Rheumatoid arthritis	-1.70	4.92e-2	78/93 (83.87%)	ATP6V0C;ITGAL;TNFRSF11A;...
Prion disease	-1.73	3.51e-2	209/273 (76.56%)	NDUFS4;PSMD1;KIF5C;...
NOD-like receptor signaling pathway	-1.74	3.76e-2	145/181 (80.11%)	BIRC2;TXNIP;BIRC3;...
Ribosome	-1.74	4.05e-2	113/158 (71.52%)	RPS23;RPL19;MRPS2;...
Tryptophan metabolism	-1.75	4.27e-2	35/42 (83.33%)	DHTKD1;TDO2;CYP1A1;...
TNF signaling pathway	-1.77	3.56e-2	103/112 (91.96%)	CFLAR;MAPK1;LTA;...
Non-alcoholic fatty liver disease	-1.77	3.78e-2	126/155 (81.29%)	MAPK11;NDUFA10;MLXIP;...
Shigellosis	-1.77	4.20e-2	180/246 (73.17%)	ARPC1A;PRKCQ;MAPK1;...
Huntington disease	-1.79	4.05e-2	233/306 (76.14%)	NDUFS4;PSMD1;HDAC2;...
Bacterial invasion of epithelial cells	-1.87	1.54e-2	59/77 (76.62%)	CRK;RHOG;ARPC5L;...
Lipid and atherosclerosis	-1.88	1.12e-2	190/215 (88.37%)	CYP1A1;RAC1;MAP3K5;...
Amoebiasis	-1.88	1.35e-2	99/102 (97.06%)	SERPINB10;ACTN4;LAMC3;...
Parkinson disease	-1.94	0.00e+0	176/249 (70.68%)	NDUFS4;PSMD1;KIF5C;...
Mitophagy	-1.98	0.00e+0	56/68 (82.35%)	RHOT1;BECN1;TAX1BP1;...
Proteasome	-2.00	0.00e+0	44/46 (95.65%)	PSMB6;PSMC1;PSMD12;...
IL-17 signaling pathway	-2.02	0.00e+0	84/94 (89.36%)	HSP90B1;DEFB4A;SRSF1;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Breast

Breast adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF7	CVCL_0031	Homo sapiens	0.01uM - 10uM	24H	Hide ▲
MDA-MB-231	CVCL_0062	Homo sapiens	0.01uM - 10uM	24H	Hide ▲

Breast epithelium

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
MCF-10A	CVCL_0598	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Cervix

Cervical adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HeLa	CVCL_0030	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Colon

Colorectal adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HT-29	CVCL_0320	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Kidney

Normal (Immortalized)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HA1E	CVCL_0284	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Normal (Transformed)

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HEK293	CVCL_0045	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Lung

Lung adenocarcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A549	CVCL_0023	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Pancreas

Pancreatic carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
YAPC	CVCL_1791	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Peripheral blood

Acute monocytic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
THP-1	CVCL_0006	Homo sapiens	0.04uM - 10uM	24H	Show ▼

T-cell acute lymphoblastic leukemia

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
Jurkat	CVCL_0367	Homo sapiens	0.04uM - 10uM	24H	Show ▼

Prostate

Prostate carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
PC-3	CVCL_0035	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Skin

Melanoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
A-375	CVCL_0132	Homo sapiens	0.01uM - 10uM	24H	Show ▼

Umbilical vein

Normal

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HUVEC-C	CVCL_2959	Homo sapiens	0.01uM - 2.22uM	24H	Show ▼