Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM6AUFY)

Drug Name
Iloperidone Drug Info
Synonyms
Fanapt; Fanapta; Fiapta; Zomaril; HP 873; Fanapt (TN); HP-873; ILO-522; Iloperidone [USAN:INN]; Fanapta, Zomaril, Iloperidone; Iloperidone (USAN/INN); 1-[4-[3-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]-3-methoxyphenyl]ethanone; 4'-(3-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)propoxy)-3'-methoxyacetophenone
Cross-matching ID
PubChem CID
71360
ChEBI ID
CHEMBL14376
CAS Number
CAS 133454-47-4
TTD Drug ID
D0M8VE
INTEDE Drug ID
DR0856
ACDINA Drug ID
D00323

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Steroid biosynthesis 2.39 0.00e+0 19/20 (95%) MSMO1;SQLE;NSDHL;...
Terpenoid backbone biosynthesis 2.14 0.00e+0 18/22 (81.82%) HMGCS1;IDI1;HMGCR;...
Biosynthesis of unsaturated fatty acids 2.01 0.00e+0 21/27 (77.78%) SCD;FADS2;FADS1;...
Butanoate metabolism 1.92 8.13e-3 23/28 (82.14%) HMGCS1;ACAT2;OXCT1;...
PPAR signaling pathway 1.91 6.51e-3 66/74 (89.19%) HMGCS1;SCD;FADS2;...
Synthesis and degradation of ketone bodies 1.89 5.42e-3 9/10 (90%) HMGCS1;ACAT2;OXCT1;...
Valine, leucine and isoleucine degradation 1.82 1.28e-2 42/48 (87.5%) HMGCS1;ACAT2;ALDH9A1;...
Fatty acid biosynthesis 1.74 2.54e-2 16/18 (88.89%) ACACA;ACSL1;ACSL3;...
Propanoate metabolism 1.69 4.97e-2 30/34 (88.24%) ACACA;ACAT2;SUCLG2;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 10uM 6H